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Table 7 Results of Simulations for Scenarios 5 and 6

From: A comparison of estimators from self-controlled case series, case-crossover design, and sequence symmetry analysis for pharmacoepidemiological studies

    Results of simulations
Scenarios Methods (Effect measures) Settings Mean of estimates (Ratio scale) Bias (Log scale) Empirical standard error Mean squared error Mean standard error Coverage (%)
5 SCCS (IRR) P C a = 0.3 3.02 0.0055 0.1019 0.0104 0.0983 93.9
  CCO (OR)   3.02 0.0053 0.2065 0.0426 0.1974 94.2
  SSA (ASR)   4.39 0.3799 0.2764 0.2206 0.2628 72.8
  SCCS (IRR) P C a = 0.6 3.06 0.0202 0.1046 0.0113 0.1001 93.1
  CCO (OR)   3.02 0.0053 0.2065 0.0426 0.1974 94.2
  SSA (ASR)   7.87 0.9647 0.3638 1.0630 0.3397 0.1
  SCCS (IRR) P C a = 1.0 3.13 0.0421 0.1088 0.0136 0.1027 90.3
  CCO (OR)   3.02 0.0053 0.2065 0.0426 0.1974 94.2
  SSA (ASR)   NA NA NA NA NA NA
6 SCCS (IRR) Restricted to patients who did not experience the event before the first exposure 5.03 0.5164 0.1040 0.2775 0.1002 0.0
  CCO (OR) 3.02 0.0053 0.2065 0.0426 0.1974 94.2
  SSA (ASR) NA NA NA NA NA NA
  1. Abbreviations ASR Adjusted sequence ratio, CCO Case-crossover, IRR Incident rate ratio, NA Not applicable, OR Odds ratio, SCCS Self-controlled case series, SSA Sequence symmetry analysis
  2. aProbability of censoring upon event occurrence
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