| | | |
Results of simulations
|
|---|
|
Scenarios
|
Methods (Effect measures)
|
Settings
|
Mean of estimates (Ratio scale)
|
Bias (Log scale)
|
Empirical standard error
|
Mean squared error
|
Mean standard error
|
Coverage (%)
|
|---|
|
5
|
SCCS (IRR)
|
P
C
a = 0.3
|
3.02
|
0.0055
|
0.1019
|
0.0104
|
0.0983
|
93.9
|
| |
CCO (OR)
| |
3.02
|
0.0053
|
0.2065
|
0.0426
|
0.1974
|
94.2
|
| |
SSA (ASR)
| |
4.39
|
0.3799
|
0.2764
|
0.2206
|
0.2628
|
72.8
|
| |
SCCS (IRR)
|
P
C
a = 0.6
|
3.06
|
0.0202
|
0.1046
|
0.0113
|
0.1001
|
93.1
|
| |
CCO (OR)
| |
3.02
|
0.0053
|
0.2065
|
0.0426
|
0.1974
|
94.2
|
| |
SSA (ASR)
| |
7.87
|
0.9647
|
0.3638
|
1.0630
|
0.3397
|
0.1
|
| |
SCCS (IRR)
|
P
C
a = 1.0
|
3.13
|
0.0421
|
0.1088
|
0.0136
|
0.1027
|
90.3
|
| |
CCO (OR)
| |
3.02
|
0.0053
|
0.2065
|
0.0426
|
0.1974
|
94.2
|
| |
SSA (ASR)
| |
NA
|
NA
|
NA
|
NA
|
NA
|
NA
|
|
6
|
SCCS (IRR)
|
Restricted to patients who did not experience the event before the first exposure
|
5.03
|
0.5164
|
0.1040
|
0.2775
|
0.1002
|
0.0
|
| |
CCO (OR)
|
3.02
|
0.0053
|
0.2065
|
0.0426
|
0.1974
|
94.2
|
| |
SSA (ASR)
|
NA
|
NA
|
NA
|
NA
|
NA
|
NA
|
- Abbreviations ASR Adjusted sequence ratio, CCO Case-crossover, IRR Incident rate ratio, NA Not applicable, OR Odds ratio, SCCS Self-controlled case series, SSA Sequence symmetry analysis
- aProbability of censoring upon event occurrence
