
Results from validation cohort


Screening algorithm

A1

B1

C1

D1

A2

B2

C2

D2


AFP only

0.5753

0.5672

0.5442

0.5388

0.4019

0.4099

0.3564

0.3361

AFP+Lab+ ΔAFP

0.6137

0.6119

0.5907

0.5809

0.4766

0.4820

0.4158

0.3770

PEB: AFP

0.6055

0.6045

0.6023

0.6364

0.4579

0.4955

0.4653

0.4891

Number of HCC cases

365

402

430

451

107

222

303

366

 A1: τ_{1}=6 months and τ_{2}=0, B1: τ_{1}=12 months and τ_{2}=0, C1: τ_{1}=24 months and τ_{2}=0, D1: τ_{1} is the maximum followup time and τ_{2}=0. A2: τ_{1}=6 months and τ_{2}=3 months, B2: τ_{1}=12 months and τ_{2}=3 months, C2: τ_{1}=24 months and τ_{2}=3 months, D2: τ_{1} is the maximum followup time and τ_{2}=3 months. AFP+Lab+ ΔAFP: updated laboratorybased algorithm, PEB: AFP: parametric empirical Bayes algorithm applied to AFP