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Fig. 3 | BMC Medical Research Methodology

Fig. 3

From: Methods to adjust for multiple comparisons in the analysis and sample size calculation of randomised controlled trials with multiple primary outcomes

Fig. 3

FWER (top) and disjunctive power (bottom) obtained when evaluating four continuous outcomes using a variety of methods to control the FWER. In the left hand graphs, there are no missing data. In the right hand graphs, the missing data are missing completely at random, with 15% missing in two outcomes and 25% missing in the other two outcomes (‘Missing data’). The graphs display various degrees of correlation between the outcomes, ranging from ρ = 0 to ρ = 0.8. The Monte Carlo standard errors (MCSE) were similar across all methods. When there was no missing data, the MCSE was between 0.001–0.004 for the disjunctive power and 0.002–0.004 for the FWER. In the missing data scenario, the MCSE was between 0.001–0.004 for the disjunctive power and between 0.001–0.004 for the FWER

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