Skip to main content

Table 3 Level- and slope-change point estimates with 95% confidence intervals (CIs), p-values and estimate of magnitude of lag-1 autocorrelation (\( {\hat{\boldsymbol{\uprho}}}_{\mathbf{est}} \)) from C difficile infection data using a range of statistical methods. Abbreviations: ARIMA, autoregressive integrated moving average; OLS, ordinary least squares; NW, Newey-West; PW, Prais-Winsten; REML, restricted maximum likelihood; Satt, Satterthwaite

From: Evaluation of statistical methods used in the analysis of interrupted time series studies: a simulation study

 

Level change

 

Slope change

 

\( {\hat{\boldsymbol{\rho}}}_{\boldsymbol{est}} \)

 

Estimate (CI)

p-value

Estimate (CI)

p-value

 

ARIMA

−0.42 (−0.89,0.05)

0.079

−0.03 (− 0.11,0.06)

0.531

0.07

OLS

−0.44 (− 0.76,-0.13)

0.008

− 0.03 (− 0.07,0.02)

0.201

N/A

NW

−0.44 (− 0.71,-0.17)

0.002

−0.03 (− 0.06,0.00)

0.069

N/A

PW

−0.42 (− 0.75,-0.09)

0.014

− 0.03 (− 0.08,0.02)

0.251

0.07

REML

−0.37 (− 0.72,-0.01)

0.044

−0.02 (− 0.08,0.03)

0.390

0.23

REML-Satt

−0.37 (− 0.82,0.09)

0.095

− 0.02 (− 0.10,0.05)

0.437

N/A