Type | Factors |
---|---|
Organisational | Centre (5 centres) Admission from nursing- or care home Length of prior in-patient stay (days) Speciality of consultant on day 0a |
Organism / infection | Organism identity (target organism group): 6 categories (ESBL producer, non-ESBL producing E.coli, MRSA, MSSA, P. aeruginosa and Candida) Source of infection (CDC criteria) |
Patient measures | Age Gender Height (cm) Weight (kg) |
Patient medical history (up to date 0) | Leukaemia within 5 years before date 0 Lymphoma within 5 years before date 0 Solid tumour within 5 years before date 0 Any other (second) tumour within 5 years before date 0 Chemotherapy in month before date 0 Surgery requiring overnight stay within 7 days before date 0 Burn requiring hospital admission within 7 days before date 0 Cardiac arrest within 7 days before date 0 Myocardial infarction, symptomatic within 7 days before date 0 Renal support within 7 days before date 0 |
Patient comorbidities ongoing at date 0 | Disease markers Ascites Diabetes without organ damage Diabetes with organ damage Chronic obstructive pulmonary disease Congestive heart failure Connective tissue disease Cerebrovascular disease Dementia Hemiplegia Peptic ulcer disease Peripheral vascular disease Potentially removable sources of infection Abscess at time 0 Infected foreign body (non-surgical) at time 0 Infected prosthesis or similar surgical item at time 0 |
Infection severity measures at or nearest before time 0 | Signs Mental Disorientation (scale 0–4) at time 0 Temperature (°C) at time 0 Systolic blood pressure (mmHg) at time 0 Early warning score at time 0 Blood tests INRb at day0, or nearest within 7 days before eGFRc (mL/min/1.73 m2) at day 0, or nearest within 7 days before Serum albumin (g/L) at day0, or nearest within 7 days before Bilirubin (total, micromol/L) at day0, or nearest within 7 days before Neutrophil count (× 109/L) at day 0, or nearest within 7 days before Interventions Receiving intravenous fluids on day 0, at or before time 0 Receiving artificial ventilation on day 0, at or before time 0 Receiving vasopressor drugs on day 0, at or before time 0 Received systemic corticosteroids in 24 h before time 0 |