Table 5 Parameters for different episode 2 non-enrolment scenarios (simulation study 2a). For all scenarios, we set \({\upalpha}^{R_2}=0.05\) and \({\upgamma}^{R_2}=0.10\)
From: Independence estimators for re-randomisation trials in multi-episode settings: a simulation study
Scenario | \({\upbeta}_{X_{PL}}\) | \({\upbeta}_{X_{EL}}\) | \({\upbeta}_{X_{PL}}^{R_2}\) | \({\upbeta}_{X_{EL}}^{R_2}\) | \({\updelta}_{Xpl}^{R_2}\) | \({\updelta}_{Xel}^{R_2}\) |
|---|---|---|---|---|---|---|
Scenario 1 – Non-enrolment depends on previous treatment allocation | 0 | 0 | 0 | 0 | 0 | 0 |
Scenario 2 – Non-enrolment depends on previous treatment allocation and previous outcome | 10 | 0 | 0.25 | 0 | 0 | 0 |
Scenario 3 – Non-enrolment depends on previous treatment allocation and baseline prognosis at episode 2 | 0 | 10 | 0 | 0.25 | 0 | 0 |
Scenario 4 – Non-enrolment is differential between treatment groups based on previous outcome | 10 | 0 | 0 | 0 | 0.5 | 0 |
Scenario 5 – Non-enrolment is differential between treatment groups based on baseline prognosis at episode 2 | 0 | 10 | 0 | 0 | 0 | 0.5 |