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Table 3 Registered targets in 81 clinical trials on genome editing in human participants from WHO ICTRP

From: Inadequate reporting quality of registered genome editing trials: an observational study

WHO ICTRP targets

No. (%) of trials

Single target

 BCL11A gene

5 (6.2)

 CCR5 gene

10 (12.3)

 CEP290 gene

1 (1.2)

 CISH gene

2 (2.5)

 Factor IX gene

2 (2.5)

 HBB gene

1 (1.2)

 HPV oncogenes E6 or E7

3 (3.7)

 IDS gene

1 (1.2)

 IDUA gene

1 (1.2)

 PDCD1 gene

15 (18.5)

 CAR T cells therapy targets:

23 (28.4)

  BCMA

3 (3.7)

  CD7

2 (2.5)

  CD19

12 (14.8)

  CD22

1 (1.2)

  CD70

2 (2.5)

  CD123

2 (2.5)

  CS1

1 (1.2)

Multiple targets

 PDCD1, NY-ESO-1, TRAC

1 (1.2)

 PDCD1, mesothelin (CARTs)

2 (2.5)

 PDCD1, CD19 (CARTs)

2 (2.5)

 PDCD1, MUC1 (CARTs)

3 (3.7)

 CCR5, CD4 (CARTs)

1 (1.2)

 CD19 and CD20/CD22 (CARTs)

1 (1.2)

 CD19 and HPK1 (CARTs)

1 (1.2)

 CD19, CD52, TRAC (CARTs)

1 (1.2)

 CD19, B2M, TRAC (CARTs)

1 (1.2)

 IL13 zetakine/HyTk (CARTs)

1 (1.2)

 CD7 and CD28 (CARTs)

1 (1.2)

Not stated

2 (2.5)

  1. Abbreviations: BCL11A Mouse B cell lymphoma factor 11A, BCMA B cell maturation antigen, B2M Beta-2-microglobulin, CAR Chimeric antigen receptor, CARTs Chimeric antigen receptor T cells, CCR5 Chemokine receptor 5, CD Cluster of differentiation, CEP290 Centrosomal protein 290, CISH Cytokine-induced SH2 protein, HBB Hemoglobin subunit beta, HPK1 Hematopoietic progenitor kinase 1, HPV Human papillomavirus, IDS Iduronate 2-sulfatase, IDUA α-L-iduronidase, MUC1 Mucin 1, cell surface associated, NY-ESO-1 New York esophageal squamous cell carcinoma 1, PDCD1 Programmed cell death 1, TRAC T cell receptor alpha chain, WHO ICTRP World Health Organization International Clinical Trial Registry Platform