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Table 1 Parameter set-up 

From: A data-driven pipeline to extract potential adverse drug reactions through prescription, procedures and medical diagnoses analysis: application to a cohort study of 2,010 patients taking hydroxychloroquine with an 11-year follow-up

Parameter

Set-up in our study

Explanation

Drug of interest

Hydroxychloroquine

drug for which we want to know all co-prescriptions after exposure

Study period

01/01/2008 to 12/31/2018

study start and stop

Time period

month

time interval between start and stop

Time window

24 months

potential exposure period before the event

Covariates

age, sex, and severity

covariate to fit the model

nknots

1

number of interior knots for the cubic spline to estimate the risk function

Bootstraps

1,000

repeat on sample of the WCE model application

Number of ATC classes

1,081

ATC classes level 5

Number of medical diagnoses

4,200

code CIM10

Number of procedures

3,075

we used “classification commune des actes médicaux”, a classification from the French National Insurance