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  1. Machine learning tools that semi-automate data extraction may create efficiencies in systematic review production. We evaluated a machine learning and text mining tool’s ability to (a) automatically extract da...

    Authors: Allison Gates, Michelle Gates, Shannon Sim, Sarah A. Elliott, Jennifer Pillay and Lisa Hartling

    Citation: BMC Medical Research Methodology 2021 21:169

    Content type: Research

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  2. Randomization is the foundation of any clinical trial involving treatment comparison. It helps mitigate selection bias, promotes similarity of treatment groups with respect to important known and unknown confo...

    Authors: Vance W. Berger, Louis Joseph Bour, Kerstine Carter, Jonathan J. Chipman, Colin C. Everett, Nicole Heussen, Catherine Hewitt, Ralf-Dieter Hilgers, Yuqun Abigail Luo, Jone Renteria, Yevgen Ryeznik, Oleksandr Sverdlov and Diane Uschner

    Citation: BMC Medical Research Methodology 2021 21:168

    Content type: Research

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  3. Few definitive guidelines exist for rigorous large-scale prospective evaluation of nonrandomized programs and policies that require longitudinal primary data collection. In Veterans Affairs (VA) we identified ...

    Authors: Valerie A. Smith, Courtney Harold Van Houtven, Jennifer H. Lindquist and Susan N. Hastings

    Citation: BMC Medical Research Methodology 2021 21:167

    Content type: Research article

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  4. A considerable proportion of SARS-CoV-2 transmission occurs from asymptomatic and pre-symptomatic cases. Therefore, different polymerase chain reaction (PCR)- or rapid antigen test (RAT)-based approaches are b...

    Authors: Ralf Krumkamp, Benno Kreuels, Veronika K. Jaeger, Jürgen May, Rafael Mikolajczyk and André Karch

    Citation: BMC Medical Research Methodology 2021 21:165

    Content type: Research article

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  5. An essential aspect of preventing further COVID-19 outbreaks and to learn for future pandemics is the evaluation of different political strategies, which aim at reducing transmission of and mortality due to CO...

    Authors: Maja von Cube, Jéan-Francois Timsit, Andreas Kammerlander and Martin Schumacher

    Citation: BMC Medical Research Methodology 2021 21:164

    Content type: Research

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  6. The COVID-19 pandemic is currently a severe challenge for healthcare workers, with a considerable impact on their mental health. In order to focus preventive and rehabilitation measures it’s fundamental to ide...

    Authors: A Fattori, F Cantù, A Comotti, V Tombola, E Colombo, C Nava, L Bordini, L Riboldi, M Bonzini and P Brambilla

    Citation: BMC Medical Research Methodology 2021 21:163

    Content type: Research

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  7. Although many studies have investigated agreement between survey and hospitalization data for disease prevalence, it is unknown whether exposure-chronic disease associations vary based on data collection metho...

    Authors: Howard E. Alper, Jennifer Brite, James E. Cone and Robert M. Brackbill

    Citation: BMC Medical Research Methodology 2021 21:162

    Content type: Research

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  8. Non-participation in cohort studies, if associated with both the exposure and occurrence of the event, can introduce bias in the estimates of interest. This study aims to identify factors associated with follo...

    Authors: Leila Cheraghi, Parisa Amiri, Golnaz Vahedi-Notash, Sara Jalali-Farahani, Davood Khalili and Fereidoun Azizi

    Citation: BMC Medical Research Methodology 2021 21:161

    Content type: Research

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  9. Data monitoring of clinical trials is a tool aimed at reducing the risks of random errors (e.g. clerical errors) and systematic errors, which include misinterpretation, misunderstandings, and fabrication. Trad...

    Authors: Markus Harboe Olsen, Mathias Lühr Hansen, Sanam Safi, Janus Christian Jakobsen, Gorm Greisen and Christian Gluud

    Citation: BMC Medical Research Methodology 2021 21:160

    Content type: Research

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  10. HIV prevention measures in sub-Saharan Africa are still short of attaining the UNAIDS 90–90-90 fast track targets set in 2014. Identifying predictors for HIV status may facilitate targeted screening interventi...

    Authors: Charles K. Mutai, Patrick E. McSharry, Innocent Ngaruye and Edouard Musabanganji

    Citation: BMC Medical Research Methodology 2021 21:159

    Content type: Research

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  11. Authors: Jan W. van der Scheer, Matthew Woodward, Akbar Ansari, Tim Draycott, Cathy Winter, Graham Martin, Karolina Kuberska, Natalie Richards, Ruth Kern and Mary Dixon-Woods

    Citation: BMC Medical Research Methodology 2021 21:156

    Content type: Correction

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    The original article was published in BMC Medical Research Methodology 2021 21:103

  12. Linking independent sources of data describing the same individuals enable innovative epidemiological and health studies but require a robust record linkage approach. We describe a hybrid record linkage proces...

    Authors: Yue Jiao, Fabienne Lesueur, Chloé-Agathe Azencott, Maïté Laurent, Noura Mebirouk, Lilian Laborde, Juana Beauvallet, Marie-Gabrielle Dondon, Séverine Eon-Marchais, Anthony Laugé, Catherine Noguès, Nadine Andrieu, Dominique Stoppa-Lyonnet and Sandrine M. Caputo

    Citation: BMC Medical Research Methodology 2021 21:155

    Content type: Research article

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  13. Collinearity is a common and problematic phenomenon in studies on public health. It leads to inflation in variance of estimator and reduces test power. This phenomenon can occur in any model. In this study, a ...

    Authors: Sanaz Khalili, Javad Faradmal, Hossein Mahjub, Babak Moeini and Khadijeh Ezzati-Rastegar

    Citation: BMC Medical Research Methodology 2021 21:154

    Content type: Research

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  14. The Iberoamerican Cochrane Network is currently developing an extensive project to identify Spanish-language journals that publish original clinical research in Spain and Latin America. The project is called B...

    Authors: Vivienne C. Bachelet, María S. Navarrete, Constanza Barrera-Riquelme, Víctor A. Carrasco, Matías Dallaserra, Rubén A. Díaz, Álvaro A. Ibarra, Francisca J. Lizana, Nicolás Meza-Ducaud, Macarena G. Saavedra, Camila Tapia-Davegno, Alonso F. Vergara and Julio Villanueva

    Citation: BMC Medical Research Methodology 2021 21:153

    Content type: Research

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  15. Cluster randomised trials (CRTs) are increasingly used to evaluate non-pharmacological interventions for improving child health. Although methodological challenges of CRTs are well documented, the characterist...

    Authors: Kitty Parker, Michael Nunns, ZhiMin Xiao, Tamsin Ford and Obioha C. Ukoumunne

    Citation: BMC Medical Research Methodology 2021 21:152

    Content type: Research

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  16. Converting electronic health record (EHR) entries to useful clinical inferences requires one to address the poor scalability of existing implementations of Generalized Linear Mixed Models (GLMM) for repeated m...

    Authors: Cristian G. Bologa, Vernon Shane Pankratz, Mark L. Unruh, Maria Eleni Roumelioti, Vallabh Shah, Saeed Kamran Shaffi, Soraya Arzhan, John Cook and Christos Argyropoulos

    Citation: BMC Medical Research Methodology 2021 21:151

    Content type: Technical advance

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  17. Initially, the Cochrane risk of bias (RoB) tool had a domain for “blinding of participants, personnel and outcome assessors”. In the 2011 tool, the assessment of blinding was split into two domains: blinding o...

    Authors: Ognjen Barcot, Matija Boric, Svjetlana Dosenovic and Livia Puljak

    Citation: BMC Medical Research Methodology 2021 21:149

    Content type: Research article

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  18. Google Trends (GT) is being used as an epidemiological tool to study coronavirus disease (COVID-19) by identifying keywords in search trends that are predictive for the COVID-19 epidemiological burden. However...

    Authors: Kenichiro Sato, Tatsuo Mano, Atsushi Iwata and Tatsushi Toda

    Citation: BMC Medical Research Methodology 2021 21:147

    Content type: Research

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  19. Already at hospital admission, clinicians require simple tools to identify hospitalized COVID-19 patients at high risk of mortality. Such tools can significantly improve resource allocation and patient managem...

    Authors: Hamid Reza Marateb, Maja von Cube, Ramin Sami, Shaghayegh Haghjooy Javanmard, Marjan Mansourian, Babak Amra, Forogh Soltaninejad, Mojgan Mortazavi, Peyman Adibi, Nilufar Khademi, Nastaran Sadat Hosseini, Arash Toghyani, Razieh Hassannejad, Miquel Angel Mañanas, Harald Binder and Martin Wolkewitz

    Citation: BMC Medical Research Methodology 2021 21:146

    Content type: Research article

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  20. A large multi-center survey was conducted to understand patients’ perspectives on biobank study participation with particular focus on racial and ethnic minorities. In order to enrich the study sample with rac...

    Authors: Aya A. Mitani, Nathaniel D. Mercaldo, Sebastien Haneuse and Jonathan S. Schildcrout

    Citation: BMC Medical Research Methodology 2021 21:145

    Content type: Research article

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  21. Case–control studies based on pharmaco-epidemiological databases typically use decision rules to determine exposure status from information on dates of prescription redemptions, although this induces misclassi...

    Authors: Henrik Støvring, Anton Pottegård and Jesper Hallas

    Citation: BMC Medical Research Methodology 2021 21:144

    Content type: Research article

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  22. Various interacting and interdependent components comprise complex interventions. These components create difficulty in assessing the true impact of interventions designed to improve patient-centered outcomes....

    Authors: Maricela Cruz, Marco A. Pinto-Orellana, Daniel L. Gillen and Hernando C. Ombao

    Citation: BMC Medical Research Methodology 2021 21:143

    Content type: Software

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  23. Standard practice for conducting systematic reviews (SRs) is time consuming and involves the study team screening hundreds or thousands of citations. As the volume of medical literature grows, the citation set...

    Authors: Katie O’Hearn, Cameron MacDonald, Anne Tsampalieros, Leo Kadota, Ryan Sandarage, Supun Kotteduwa Jayawarden, Michele Datko, John M. Reynolds, Thanh Bui, Shagufta Sultan, Margaret Sampson, Misty Pratt, Nick Barrowman, Nassr Nama, Matthew Page and James Dayre McNally

    Citation: BMC Medical Research Methodology 2021 21:142

    Content type: Research

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  24. Children are more vulnerable to adverse drug reactions (ADRs) due to complex changes in the body during the growth process and lack specific pharmacoepidemiologic studies. Causality and Avoidability assessment...

    Authors: Elisangela da Costa Lima, Thais de Barros Fernandes, Adair Freitas, Juliana Freire de Lima Sias, Marcelo Gerardin Poirot Land, Mariana Tschoepke Aires, Louise Bracken and Matthew Peak

    Citation: BMC Medical Research Methodology 2021 21:141

    Content type: Research

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  25. Overviews often identify and synthesise a large number of systematic reviews on the same topic, which is likely to lead to overlap (i.e. duplication) in primary studies across the reviews. Using a primary stud...

    Authors: Carole Lunny, Dawid Pieper, Pierre Thabet and Salmaan Kanji

    Citation: BMC Medical Research Methodology 2021 21:140

    Content type: Research article

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  26. Clustering of observations is a common phenomenon in epidemiological and clinical research. Previous studies have highlighted the importance of using multilevel analysis to account for such clustering, but in ...

    Authors: Georgia Ntani, Hazel Inskip, Clive Osmond and David Coggon

    Citation: BMC Medical Research Methodology 2021 21:139

    Content type: Research article

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  27. Hometime, the total number of days a person is living in the community (not in a healthcare institution) in a defined period of time after a hospitalization, is a patient-centred outcome metric increasingly us...

    Authors: Jessalyn K. Holodinsky, Amy Y. X. Yu, Moira K. Kapral and Peter C. Austin

    Citation: BMC Medical Research Methodology 2021 21:138

    Content type: Research article

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  28. Confounding bias is a common concern in epidemiological research. Its presence is often determined by comparing exposure effects between univariable- and multivariable regression models, using an arbitrary thr...

    Authors: Noah A. Schuster, Jos W. R. Twisk, Gerben ter Riet, Martijn W. Heymans and Judith J. M. Rijnhart

    Citation: BMC Medical Research Methodology 2021 21:136

    Content type: Research

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  29. Clustered data arise in research when patients are clustered within larger units. Generalised Estimating Equations (GEE) and Generalised Linear Models (GLMM) can be used to provide marginal and cluster-specifi...

    Authors: Menelaos Pavlou, Gareth Ambler and Rumana Z. Omar

    Citation: BMC Medical Research Methodology 2021 21:135

    Content type: Research article

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  30. The Interrupted Time Series (ITS) is a quasi-experimental design commonly used in public health to evaluate the impact of interventions or exposures. Multiple statistical methods are available to analyse data ...

    Authors: Simon L. Turner, Amalia Karahalios, Andrew B. Forbes, Monica Taljaard, Jeremy M. Grimshaw and Joanne E. McKenzie

    Citation: BMC Medical Research Methodology 2021 21:134

    Content type: Research

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  31. Developing effective implementation strategies requires adequate tracking and reporting on their application. Guidelines exist for defining and reporting on implementation strategy characteristics, but not for...

    Authors: Amber D. Haley, Byron J. Powell, Callie Walsh-Bailey, Molly Krancari, Inga Gruß, Christopher M. Shea, Arwen Bunce, Miguel Marino, Leah Frerichs, Kristen Hassmiller Lich and Rachel Gold

    Citation: BMC Medical Research Methodology 2021 21:133

    Content type: Research

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  32. Despite experimental evidence suggesting that pain sensitivity is not impaired by cognitive impairment, observational studies in nursing home residents have observed an inverse association between cognitive im...

    Authors: Anthony P. Nunes, Danni Zhao, William M. Jesdale and Kate L. Lapane

    Citation: BMC Medical Research Methodology 2021 21:132

    Content type: Research article

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  33. Most older adults prefer to continue living at home despite increasing care needs and demand for services. To aid in maintaining independence, integrated care models for community-dwelling older people are pro...

    Authors: Flaka Siqeca, Katrina Obas, Olivia Yip, Samuel Stenz, Penelope Vounatsou, Matthias Briel, Matthias Schwenkglenks, Carlos Quinto, Eva Blozik, Andreas Zeller, Leah L. Zullig, Sabina De Geest and Mieke Deschodt

    Citation: BMC Medical Research Methodology 2021 21:131

    Content type: Research

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  34. Childhood obesity has increased remarkably in low and middle-income (LMIC) countries. Movement behaviors (physical activity, screen time, and sleep) are crucial in the development of overweight and obesity in ...

    Authors: Widjane Sheila Ferreira Goncalves, Rebecca Byrne, Pedro Israel Cabral de Lira, Marcelo Tavares Viana and Stewart G. Trost

    Citation: BMC Medical Research Methodology 2021 21:129

    Content type: Research

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  35. Patient-Reported Outcomes (PROs) are standardized questionnaires used to measure subjective outcomes such as quality of life in healthcare. They are considered paramount to assess the results of therapeutic in...

    Authors: Antoine Vanier, Véronique Sébille, Myriam Blanchin and Jean-Benoit Hardouin

    Citation: BMC Medical Research Methodology 2021 21:128

    Content type: Research article

    Published on:

  36. Kidney graft failure risk prediction models assist evidence-based medical decision-making in clinical practice. Our objective was to develop and validate statistical and machine learning predictive models to p...

    Authors: Sameera Senanayake, Sanjeewa Kularatna, Helen Healy, Nicholas Graves, Keshwar Baboolal, Matthew P. Sypek and Adrian Barnett

    Citation: BMC Medical Research Methodology 2021 21:127

    Content type: Research

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  37. Mortality is a key component of the natural history of COVID-19 infection. Surveillance data on COVID-19 deaths and case diagnoses are widely available in the public domain, but they are not used to model time...

    Authors: Ian C. Marschner

    Citation: BMC Medical Research Methodology 2021 21:126

    Content type: Research

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  38. Q-methodology is an approach to studying complex issues of human ‘subjectivity’. Although this approach was developed in the early twentieth century, the value of Q-methodology in healthcare was not recognised...

    Authors: Kate Churruca, Kristiana Ludlow, Wendy Wu, Kate Gibbons, Hoa Mi Nguyen, Louise A. Ellis and Jeffrey Braithwaite

    Citation: BMC Medical Research Methodology 2021 21:125

    Content type: Research

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  39. Mortality modelling in the critical care paradigm traditionally uses logistic regression, despite the availability of estimators commonly used in alternate disciplines. Little attention has been paid to covari...

    Authors: John L. Moran, John D. Santamaria and Graeme J. Duke

    Citation: BMC Medical Research Methodology 2021 21:124

    Content type: Research article

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  40. Due to clinical and methodological diversity, clinical studies included in meta-analyses often differ in ways that lead to differences in treatment effects across studies. Meta-regression analysis is generally...

    Authors: Michael Geissbühler, Cesar A. Hincapié, Soheila Aghlmandi, Marcel Zwahlen, Peter Jüni and Bruno R. da Costa

    Citation: BMC Medical Research Methodology 2021 21:123

    Content type: Research

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  41. Attrition is a major obstacle for lifestyle interventions sustained for the medium-to-long term and can have significant consequences on the internal validity of a trial. When the degree of attrition differs b...

    Authors: Bevens W, Shoushtari A, Jelinek P, Jelinek GA and Weiland TJ

    Citation: BMC Medical Research Methodology 2021 21:122

    Content type: Research

    Published on:

  42. The International Classification of Functioning, Disability, and Health (ICF) Generic-30 (Rehabilitation) Set is a tool used to assess the functioning of a clinical population in rehabilitation. The ICF Generi...

    Authors: Yuki Senju, Masahiko Mukaino, Birgit Prodinger, Melissa Selb, Yuki Okouchi, Kouji Mizutani, Megumi Suzuki, Shin Yamada, Shin-Ichi Izumi, Shigeru Sonoda, Yohei Otaka, Eiichi Saitoh and Gerold Stucki

    Citation: BMC Medical Research Methodology 2021 21:121

    Content type: Research

    Published on:

  43. Pandemic events often trigger a surge of clinical trial activity aimed at rapidly evaluating therapeutic or preventative interventions. Ensuring rapid public access to the complete and unbiased trial record is...

    Authors: Christopher W. Jones, Amanda C. Adams, Elizabeth Murphy, Rachel P. King, Benjamin Saracco, Karen R. Stesis, Susan Cavanaugh, Brian W. Roberts and Timothy F. Platts-Mills

    Citation: BMC Medical Research Methodology 2021 21:120

    Content type: Research article

    Published on:

  44. Loss to follow-up is a major challenge for very preterm (VPT) cohorts; attrition is associated with social disadvantage and parents with impaired children may participate less in research. We investigated the ...

    Authors: Aurélie Piedvache, Stef van Buuren, Henrique Barros, Ana Isabel Ribeiro, Elizabeth Draper and Jennifer Zeitlin

    Citation: BMC Medical Research Methodology 2021 21:118

    Content type: Research article

    Published on:

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