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  1. Research has shown inconsistencies in results and difficulties in conceptualization of assessment of socioeconomic status (SES) among adolescents. The aim of this study was thus to test the validity of self-re...

    Authors: P. Svedberg, J. M. Nygren, C. Staland-Nyman and M. Nyholm
    Citation: BMC Medical Research Methodology 2016 16:48
    Content type: Research article Published on:

  2. Several indirect comparison methods, including network meta-analyses (NMAs), using individual patient data (IPD) have been developed to synthesize evidence from a network of trials. Although IPD indirect compa...

    Authors: Areti Angeliki Veroniki, Sharon E. Straus, Charlene Soobiah, Meghan J. Elliott and Andrea C. Tricco
    Citation: BMC Medical Research Methodology 2016 16:47
    Content type: Research article Published on:

  3. The UK population is ageing; improved understanding of risk factors for hospital admission is required. Linkage of the Hertfordshire Cohort Study (HCS) with Hospital Episode Statistics (HES) data has created a...

    Authors: Leo D. Westbury, Holly E. Syddall, Shirley J. Simmonds, Cyrus Cooper and Avan Aihie Sayer
    Citation: BMC Medical Research Methodology 2016 16:46
    Content type: Technical advance Published on:

  4. To be able to make valid inferences on stated preference data from a Discrete Choice Experiment (DCE) it is essential that researchers know if participants were actively involved, understood and interpreted th...

    Authors: Jorien Veldwijk, Domino Determann, Mattijs S. Lambooij, Janine A. van Til, Ida J. Korfage, Esther W. de Bekker-Grob and G. Ardine de Wit
    Citation: BMC Medical Research Methodology 2016 16:45
    Content type: Research article Published on:

  5. Emerging communication technologies have had an impact on population-based telephone surveys worldwide. Our objective was to examine the potential biases of health estimates in South Australia, a state of Aust...

    Authors: Eleonora Dal Grande, Catherine R. Chittleborough, Stefano Campostrini and Anne W. Taylor
    Citation: BMC Medical Research Methodology 2016 16:44
    Content type: Research article Published on:

  6. The primary analysis in a longitudinal randomized controlled trial is sometimes a comparison of arms at a single time point. While a two-sample t-test is often used, missing data are common in longitudinal studie...

    Authors: Erin L. Ashbeck and Melanie L. Bell
    Citation: BMC Medical Research Methodology 2016 16:43
    Content type: Research article Published on:

  7. Although covariate adjustment in the analysis of randomised trials can be beneficial, adjustment for continuous covariates is complicated by the fact that the association between covariate and outcome must be ...

    Authors: Brennan C. Kahan, Helen Rushton, Tim P. Morris and Rhian M. Daniel
    Citation: BMC Medical Research Methodology 2016 16:42
    Content type: Research article Published on:

  8. Regression models are widely used to link serial measures of anthropometric size or changes in size to a later outcome. Different parameterisations of these models enable one to target different questions abou...

    Authors: Andrew K. Wills, Bjørn Heine Strand, Kari Glavin, Richard J. Silverwood and Ragnhild Hovengen
    Citation: BMC Medical Research Methodology 2016 16:41
    Content type: Research article Published on:

  9. Regular and timely monitoring of blood glucose (BG) levels in hospitalized patients with diabetes mellitus is crucial to optimizing inpatient glycaemic control. However, methods to quantify timeliness as a mea...

    Authors: Ying Chen, Shih Ling Kao, E-Shyong Tai, Hwee Lin Wee, Eric Yin Hao Khoo, Yilin Ning, Mark Kevin Salloway, Xiaodong Deng and Chuen Seng Tan
    Citation: BMC Medical Research Methodology 2016 16:40
    Content type: Research article Published on:

  10. The use of comprehensive instruments for guideline appraisal is time-consuming and requires highly qualified personnel. Since practicing physicians are generally busy, the rapid-assessment Mini-Checklist (MiCh...

    Authors: Andrea Siebenhofer, Thomas Semlitsch, Thomas Herborn, Ulrich Siering, Ina Kopp and Johannes Hartig
    Citation: BMC Medical Research Methodology 2016 16:39
    Content type: Research article Published on:

  11. Observational post-marketing assessment studies often involve evaluating the effect of a rare treatment on a time-to-event outcome, through the estimation of a marginal hazard ratio. Propensity score (PS) meth...

    Authors: David Hajage, Florence Tubach, Philippe Gabriel Steg, Deepak L. Bhatt and Yann De Rycke
    Citation: BMC Medical Research Methodology 2016 16:38
    Content type: Research Article Published on:

  13. The ethical, methodological, and technical aspects of pediatric research, often results in complications and delays in implementation. Our objective was to identify factors associated with the implementation d...

    Authors: Delphine Meier-Girard, Annick Tibi, Hendy Abdoul, Sonia Prot-Labarthe, Françoise Brion, Olivier Bourdon and Corinne Alberti
    Citation: BMC Medical Research Methodology 2016 16:36
    Content type: Research article Published on:

  14. There is an increasing number of meta-analyses including data from non-randomized studies for therapeutic evaluation. We aimed to systematically assess the methods used in meta-analyses including non-randomize...

    Authors: Timor Faber, Philippe Ravaud, Carolina Riveros, Elodie Perrodeau and Agnes Dechartres
    Citation: BMC Medical Research Methodology 2016 16:35
    Content type: Research article Published on:

  15. Electronic administrative data exist in several domains which, if linked, are potentially useful for research. However, benefits from data linkage should be considered alongside risks such as the threat to pri...

    Authors: Suzanne Audrey, Lindsey Brown, Rona Campbell, Andy Boyd and John Macleod
    Citation: BMC Medical Research Methodology 2016 16:34
    Content type: Research article Published on:

  16. Although some nonparametric methods have been proposed in the literature to test for the equality of median survival times for censored data in medical research, in general they have inflated type I error rate...

    Authors: Zhongxue Chen and Guoyi Zhang
    Citation: BMC Medical Research Methodology 2016 16:33
    Content type: Technical advance Published on:

  17. Rates of youth violence are disproportionately high in many low- and middle-income countries [LMICs] but existing reviews of risk factors focus almost exclusively on high-income countries. Different search str...

    Authors: Yulia Shenderovich, Manuel Eisner, Christopher Mikton, Frances Gardner, Jianghong Liu and Joseph Murray
    Citation: BMC Medical Research Methodology 2016 16:32
    Content type: Research article Published on:

  20. Clustering commonly affects the uncertainty of parameter estimates in epidemiological studies. Cluster-robust variance estimates (CRVE) are used to construct confidence intervals that account for single-level ...

    Authors: Christian Bottomley, Matthew J. Kirby, Steve W. Lindsay and Neal Alexander
    Citation: BMC Medical Research Methodology 2016 16:29
    Content type: Research Article Published on:

  21. The understanding of changes in temporal processes related to human carcinogenesis is limited. One approach for prospective functional genomic studies is to compile trajectories of differential expression of g...

    Authors: Eiliv Lund, Lars Holden, Hege Bøvelstad, Sandra Plancade, Nicolle Mode, Clara-Cecilie Günther, Gregory Nuel, Jean-Christophe Thalabard and Marit Holden
    Citation: BMC Medical Research Methodology 2016 16:28
    Content type: Research article Published on:

  22. A wide-ranging debate has taken place in recent years on mediation analysis and causal modelling, raising profound theoretical, philosophical and methodological questions. The authors build on the results of t...

    Authors: Jonathan Pratschke, Trutz Haase, Harry Comber, Linda Sharp, Marianna de Camargo Cancela and Howard Johnson
    Citation: BMC Medical Research Methodology 2016 16:27
    Content type: Research article Published on:

  23. This paper explores the importance of electronic medical records (EMR) for predicting 30-day all-cause non-elective readmission risk of patients and presents a comparison of prediction performance of commonly ...

    Authors: Liping Tong, Cole Erdmann, Marina Daldalian, Jing Li and Tina Esposito
    Citation: BMC Medical Research Methodology 2016 16:26
    Content type: Research article Published on:

  24. Clinician surveys provide critical information about many facets of health care, but are often challenging to implement. Our objective was to assess use by participants and non-participants of a prepaid gift c...

    Authors: Jane S. Chen, Brian L. Sprague, Carrie N. Klabunde, Anna N. A. Tosteson, Asaf Bitton, Tracy Onega, Charles D. MacLean, Kimberly Harris, Marilyn M. Schapira and Jennifer S. Haas
    Citation: BMC Medical Research Methodology 2016 16:25
    Content type: Research article Published on:

  26. As gait speed and transfer times are considered to be an important measure of functional ability in older adults, several systems are currently being researched to measure this parameter in the home environmen...

    Authors: Greet Baldewijns, Stijn Luca, Bart Vanrumste and Tom Croonenborghs
    Citation: BMC Medical Research Methodology 2016 16:23
    Content type: Research Article Published on:

  27. Comparative performance of the traditional propensity score (PS) and high-dimensional propensity score (hdPS) methods in the adjustment for confounding by indication remains unclear. We aimed to identify which...

    Authors: Jason R. Guertin, Elham Rahme, Colin R. Dormuth and Jacques LeLorier
    Citation: BMC Medical Research Methodology 2016 16:22
    Content type: Research article Published on:

  28. An increasing number of qualitative evidence syntheses papers are found in health care literature. Many of these syntheses use a strictly exhaustive search strategy to collect articles, mirroring the standard ...

    Authors: Charlotte Benoot, Karin Hannes and Johan Bilsen
    Citation: BMC Medical Research Methodology 2016 16:21
    Content type: Technical advance Published on:

  29. It is well recognized that treatment effects may not be homogeneous across the study population. Subgroup analyses constitute a fundamental step in the assessment of evidence from confirmatory (Phase III) clin...

    Authors: Julien Tanniou, Ingeborg van der Tweel, Steven Teerenstra and Kit C. B. Roes
    Citation: BMC Medical Research Methodology 2016 16:20
    Content type: Research article Published on:

  31. Blinding is a pivotal method to avoid bias in randomised clinical trials. In blinded drug trials, experimental and control interventions are often designed to be matched, i.e. to appear indistinguishable. It i...

    Authors: Segun Bello, Maoling Wei, Jørgen Hilden and Asbjørn Hróbjartsson
    Citation: BMC Medical Research Methodology 2016 16:18
    Content type: Research article Published on:

  33. Most randomized controlled trials with a time-to-event outcome are designed assuming proportional hazards (PH) of the treatment effect. The sample size calculation is based on a logrank test. However, non-prop...

    Authors: Patrick Royston and Mahesh K.B. Parmar
    Citation: BMC Medical Research Methodology 2016 16:16
    Content type: Research Article Published on:

  34. Scoping reviews are used to identify knowledge gaps, set research agendas, and identify implications for decision-making. The conduct and reporting of scoping reviews is inconsistent in the literature. We cond...

    Authors: Andrea C. Tricco, Erin Lillie, Wasifa Zarin, Kelly O’Brien, Heather Colquhoun, Monika Kastner, Danielle Levac, Carmen Ng, Jane Pearson Sharpe, Katherine Wilson, Meghan Kenny, Rachel Warren, Charlotte Wilson, Henry T. Stelfox and Sharon E. Straus
    Citation: BMC Medical Research Methodology 2016 16:15
    Content type: Research article Published on:

  35. Biomarkers of exposures such as infection or environmental chemicals can be measured in small volumes of blood extracted from newborn dried blood spots (DBS) underscoring their potential utility for population...

    Authors: Edwina H. Yeung, Germaine Buck Louis, David Lawrence, Kurunthachalam Kannan, Alexander C. McLain, Michele Caggana, Charlotte Druschel and Erin Bell
    Citation: BMC Medical Research Methodology 2016 16:14
    Content type: Research article Published on:

  36. Verbal autopsy (VA), the process of interviewing a deceased’s family or caregiver about signs and symptoms leading up to death, employs tools that ask a series of closed questions and can include an open narra...

    Authors: C. King, C. Zamawe, M. Banda, N. Bar-Zeev, J. Beard, J. Bird, A. Costello, P. Kazembe, D. Osrin and E. Fottrell
    Citation: BMC Medical Research Methodology 2016 16:13
    Content type: Research article Published on:

  38. Inefficient experimental designs are common in animal-based biomedical research, wasting resources and potentially leading to unreplicable results. Here we illustrate the intrinsic statistical power of split-p...

    Authors: Michael Walker, Carole Fureix, Rupert Palme, Jonathan A. Newman, Jamie Ahloy Dallaire and Georgia Mason
    Citation: BMC Medical Research Methodology 2016 16:11
    Content type: Research article Published on:

  39. Health care researchers working in the Arabian Gulf need information on how to optimize recruitment and retention of study participants in extremely culturally diverse settings. Implemented in Doha, Qatar in 2...

    Authors: Amal Khidir, Humna Asad, Huda Abdelrahim, Maha Elnashar, Amal Killawi, Maya Hammoud, Abdul Latif Al-Khal, Pascale Haddad and Michael D. Fetters
    Citation: BMC Medical Research Methodology 2016 16:10
    Content type: Research article Published on:

  40. Despite randomization, baseline imbalance and confounding bias may occur in cluster randomized trials (CRTs). Covariate imbalance may jeopardize the validity of statistical inferences if they occur on prognost...

    Authors: Clémence Leyrat, Agnès Caille, Yohann Foucher and Bruno Giraudeau
    Citation: BMC Medical Research Methodology 2016 16:9
    Content type: Research Article Published on:

  41. Mortality statistics are used to compare health status of populations; optimally, they base on individual death certificates. However, determining cause of death is error-prone. E.g. cardiovascular disease (CV...

    Authors: Andreas Deckert
    Citation: BMC Medical Research Methodology 2016 16:8
    Content type: Research article Published on:

  42. As a part of a larger Health Technology Assessment (HTA), the measurement error of a device used to monitor the hemoglobin concentration of a patient undergoing surgery, as well as its decision consequences, w...

    Authors: Emmanuel Charpentier, Vincent Looten, Björn Fahlgren, Alexandre Barna and Loïc Guillevin
    Citation: BMC Medical Research Methodology 2016 16:7
    Content type: Research Article Published on:

  43. To describe approaches used in systematic reviews of diagnostic test accuracy studies for assessing variability in estimates of accuracy between studies and to provide guidance in this area.

    Authors: Christiana A. Naaktgeboren, Eleanor A. Ochodo, Wynanda A. Van Enst, Joris A. H. de Groot, Lotty Hooft, Mariska M. G. Leeflang, Patrick M. Bossuyt, Karel G. M. Moons and Johannes B. Reitsma
    Citation: BMC Medical Research Methodology 2016 16:6
    Content type: Research article Published on:

  44. In many studies, some information might not be available for the whole cohort, some covariates, or even the outcome, might be ascertained in selected subsamples. These studies are part of a broad category term...

    Authors: Paola Rebora, Laura Antolini, David V. Glidden and Maria Grazia Valsecchi
    Citation: BMC Medical Research Methodology 2016 16:5
    Content type: TECHNICAL ADVANCE Published on:

  45. There are inherent methodological challenges in the measurement of mental health problems in longitudinal research. There is constant development in definitions, taxonomies and demands concerning the propertie...

    Authors: Anne Hammarström, Hugo Westerlund, Kaisa Kirves, Karina Nygren, Pekka Virtanen and Bruno Hägglöf
    Citation: BMC Medical Research Methodology 2016 16:4
    Content type: Research article Published on:

  46. In randomized clinical trials or observational studies, it is common to collect biomarker values longitudinally on a cohort of individuals. The investigators may be interested in grouping individuals that shar...

    Authors: Claire Burny, Muriel Rabilloud, François Golfier, Jérôme Massardier, Touria Hajri, Anne-Marie Schott and Fabien Subtil
    Citation: BMC Medical Research Methodology 2016 16:3
    Content type: Research article Published on:

  47. Traditional analyses of standard case-control studies using logistic regression do not allow estimation of time-varying associations between exposures and the outcome. We present two approaches which allow thi...

    Authors: Ruth H. Keogh, Punam Mangtani, Laura Rodrigues and Patrick Nguipdop Djomo
    Citation: BMC Medical Research Methodology 2016 16:2
    Content type: Research article Published on:

  48. Evidence mapping is an emerging tool used to systematically identify, organize and summarize the quantity and focus of scientific evidence on a broad topic, but there are currently no methodological standards....

    Authors: Ding Ding Wang, Marissa Shams-White, Oliver John M. Bright, J. Scott Parrott and Mei Chung
    Citation: BMC Medical Research Methodology 2016 16:1
    Content type: Research article Published on:

  49. Chalmers and Glasziou’s paper published in 2014 recommends research funding bodies should mandate that proposals for additional primary research are built on systematic reviews of existing evidence showing wha...

    Authors: Sheetal Bhurke, Andrew Cook, Anna Tallant, Amanda Young, Elaine Williams and James Raftery
    Citation: BMC Medical Research Methodology 2015 15:108
    Content type: Research article Published on:

  50. A scaled logit model has previously been proposed to quantify the relationship between an immunological assay and protection from disease, and has been applied in a number of settings. The probability of disea...

    Authors: Andrew J. Dunning, Jennifer Kensler, Laurent Coudeville and Fabrice Bailleux
    Citation: BMC Medical Research Methodology 2015 15:107
    Content type: Research article Published on:
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BMC Medical Research Methodology

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