| | |
All ACTG studies
|
Excluding substudies
|
|---|
|
Parameters
| |
Effect (95% CI)
|
Effect (95% CI)
|
|---|
|
AR1
| |
0.04 (-0.37, 0.46)
|
-0.09 (-0.51, 0.33)
|
|
Time trend effect
| |
29.7 (18.9, 40.5) ‡
|
12.8 (3.9, 21.7) §
|
|
(per quarter)
| | | |
|
Large studies effect *(per point weight)
|
699.7 (535.5, 864.0) ‡
|
420.3 (284.2, 556.4) ‡
|
|
Early starting effect †
| |
-83.3 (-427.3, 260.7)
|
-436.7 (-731.1,-142.2) §
|
|
Studies starting in same quarter (per study)
|
20.6 (-1.4, 42.5)
|
-1.0 (-23.5, 21.4)
|
|
Seasonal effect
| | | |
| |
Spring
|
152.7 (-78.8, 406.2)
|
189.3 (-32.4, 410.9)
|
| |
Summer
|
185.3 (-43.2, 413.7)
|
115.3 (-90.6, 321.2)
|
| |
Fall
|
-144.5 (-365.2, 76.2)
|
-96.7 (-308.8, 115.4)
|
|
Constant
| |
137.5 (-152.2, 427.2)
|
576.5 (309.3, 843.7) ‡
|
- ACTG: AIDS Clinical Trials Group, AR1: First-order autoregressive parameter * Sum of weights for large studies in each quarter: ½ for a large study which is initiated in that quarter, 1 for a large study which is on its second quarter of enrollment, and ½ for a large study which is on its third quarter of enrollment. † Dummy variable for first 3 quarters (Fall 1986-Spring 1987) ‡ p < 0.001 §0.001 ≤ p < 0.05
