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  1. Recent evidence suggests that there is often substantial variation in the benefits and harms across a trial population. We aimed to identify regression modeling approaches that assess heterogeneity of treatmen...

    Authors: Alexandros Rekkas, Jessica K. Paulus, Gowri Raman, John B. Wong, Ewout W. Steyerberg, Peter R. Rijnbeek, David M. Kent and David van Klaveren

    Citation: BMC Medical Research Methodology 2020 20:264

    Content type: Research article

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  2. For outcomes that studies report as the means in the treatment and control groups, some medical applications and nearly half of meta-analyses in ecology express the effect as the ratio of means (RoM), also cal...

    Authors: Ilyas Bakbergenuly, David C. Hoaglin and Elena Kulinskaya

    Citation: BMC Medical Research Methodology 2020 20:263

    Content type: Research article

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  3. Interest in models for calculating the risk of death in traumatic patients admitted to ICUs remains high. These models use variables derived from the deviation of physiological parameters and/or the severity o...

    Authors: Luis Serviá, Neus Montserrat, Mariona Badia, Juan Antonio Llompart-Pou, Jesús Abelardo Barea-Mendoza, Mario Chico-Fernández, Marcelino Sánchez-Casado, José Manuel Jiménez, Dolores María Mayor and Javier Trujillano

    Citation: BMC Medical Research Methodology 2020 20:262

    Content type: Research article

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  4. Network meta-analysis (NMA) provides a powerful tool for the simultaneous evaluation of multiple treatments by combining evidence from different studies, allowing for direct and indirect comparisons between tr...

    Authors: Andreas Heinecke, Marta Tallarita and Maria De Iorio

    Citation: BMC Medical Research Methodology 2020 20:261

    Content type: Research article

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  5. A competing interest is an important source of bias in research and disclosure is frequently employed as a strategy to manage it. Considering the importance of systematic reviews (SRs) and the varying prevalen...

    Authors: Jiajie Yu, Guanyue Su, Allison Hirst, Zhengyue Yang, You Zhang and Youping Li

    Citation: BMC Medical Research Methodology 2020 20:260

    Content type: Research article

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  6. Data extraction forms link systematic reviews with primary research and provide the foundation for appraising, analysing, summarising and interpreting a body of evidence. This makes their development, pilot te...

    Authors: Roland Brian Büchter, Alina Weise and Dawid Pieper

    Citation: BMC Medical Research Methodology 2020 20:259

    Content type: Research article

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  7. Unstructured data from clinical epidemiological studies can be valuable and easy to obtain. However, it requires further extraction and processing for data analysis. Doing this manually is labor-intensive, slo...

    Authors: Robert Chen, Joyce C. Ho and Jin-Mann S. Lin

    Citation: BMC Medical Research Methodology 2020 20:258

    Content type: Research article

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  8. Projection of future cancer incidence is an important task in cancer epidemiology. The results are of interest also for biomedical research and public health policy. Age-Period-Cohort (APC) models, usually bas...

    Authors: Maximilian Knoll, Jennifer Furkel, Jürgen Debus, Amir Abdollahi, André Karch and Christian Stock

    Citation: BMC Medical Research Methodology 2020 20:257

    Content type: Research article

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  9. Systematic reviews often require substantial resources, partially due to the large number of records identified during searching. Although artificial intelligence may not be ready to fully replace human review...

    Authors: C. Hamel, S. E. Kelly, K. Thavorn, D. B. Rice, G. A. Wells and B. Hutton

    Citation: BMC Medical Research Methodology 2020 20:256

    Content type: Research article

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  10. Dietary patterns were associated with the risk of chronic disease development and outcome-related diseases. In this study, we aimed to compare the correlation between dietary patterns and metabolic syndrome (M...

    Authors: Adi Lukas Kurniawan, Chien-Yeh Hsu, Hsiu-An Lee, Hsiao-Hsien Rau, Rathi Paramastri, Ahmad Syauqy and Jane C.-J. Chao

    Citation: BMC Medical Research Methodology 2020 20:255

    Content type: Research article

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  11. There is a call for valid and reliable instruments to evaluate implementation of evidence-based practices (EBP). The 15-item Evidence-Based Practice Attitude Scale (EBPAS) measures attitude toward EBP, incorpo...

    Authors: Anna Helena Elisabeth Santesson, Martin Bäckström, Robert Holmberg, Sean Perrin and Håkan Jarbin

    Citation: BMC Medical Research Methodology 2020 20:254

    Content type: Research article

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  12. Go/no-go decisions after phase II and sample size chosen for phase III are usually based on phase II results (e.g., the treatment effect estimate of phase II). Due to the decision rule (only promising phase II...

    Authors: Stella Erdmann, Marietta Kirchner, Heiko Götte and Meinhard Kieser

    Citation: BMC Medical Research Methodology 2020 20:253

    Content type: Research article

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  13. Web-surveys are increasingly used in population studies. Yet, web-surveys targeting older individuals are still uncommon for various reasons. However, with younger cohorts approaching older age, the potentials...

    Authors: Susanne Kelfve, Marie Kivi, Boo Johansson and Magnus Lindwall

    Citation: BMC Medical Research Methodology 2020 20:252

    Content type: Research article

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  14. In health research, population estimates are generally obtained from probability-based surveys. In market research surveys are frequently conducted from volunteer web panels. Propensity score adjustment (PSA) ...

    Authors: Andrew Copas, Sarah Burkill, Fred Conrad, Mick P. Couper and Bob Erens

    Citation: BMC Medical Research Methodology 2020 20:251

    Content type: Research article

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  15. Dropout is a common problem in longitudinal clinical trials and cohort studies, and is of particular concern when dropout occurs for reasons that may be related to the outcome of interest. This paper reviews c...

    Authors: Camille M. Moore, Samantha MaWhinney, Nichole E. Carlson and Sarah Kreidler

    Citation: BMC Medical Research Methodology 2020 20:250

    Content type: Research article

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  16. Men, particularly those living in disadvantaged areas, are less likely to participate in weight management programmes than women despite similar levels of excess weight. Little is known about how best to recru...

    Authors: Matthew D. McDonald, Stephan U. Dombrowski, Rebecca Skinner, Eileen Calveley, Paula Carroll, Andrew Elders, Cindy M. Gray, Mark Grindle, Fiona M. Harris, Claire Jones and Pat Hoddinott

    Citation: BMC Medical Research Methodology 2020 20:249

    Content type: Research article

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  17. Classic epidemic curves – counts of daily events or cumulative events over time –emphasise temporal changes in the growth or size of epidemic outbreaks. Like any graph, these curves have limitations: they are ...

    Authors: Thomas Perneger, Antoine Kevorkian, Thierry Grenet, Hubert Gallée and Angèle Gayet-Ageron

    Citation: BMC Medical Research Methodology 2020 20:248

    Content type: Technical advance

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  18. Acute Care Surgery (ACS) was developed as a structured, team-based approach to providing round-the-clock emergency general surgery (EGS) care for adult patients needing treatment for diseases such as cholecyst...

    Authors: Heena P. Santry, Scott A. Strassels, Angela M. Ingraham, Wendelyn M. Oslock, Kevin B. Ricci, Anghela Z. Paredes, Victor K. Heh, Holly E. Baselice, Amy P. Rushing, Adrian Diaz, Vijaya T. Daniel, M. Didem Ayturk and Catarina I. Kiefe

    Citation: BMC Medical Research Methodology 2020 20:247

    Content type: Research article

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  19. The German Research Foundation (DFG) and the Federal Ministry of Education and Research (BMBF) initiated large research programs to foster high quality clinical research in the academic area. These investigato...

    Authors: E. Nury, K. Bischoff, K. Wollmann, K. Nitschke, S. Lohner, M. Schumacher, G. Rücker and A. Blümle

    Citation: BMC Medical Research Methodology 2020 20:246

    Content type: Research article

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  20. Guidelines on public health and health system interventions often involve considerations beyond effectiveness and safety to account for the impact that these interventions have on the wider systems in which th...

    Authors: A. Movsisyan, E. Rehfuess and S. L. Norris

    Citation: BMC Medical Research Methodology 2020 20:245

    Content type: Review

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  21. Researchers often misinterpret and misrepresent statistical outputs. This abuse has led to a large literature on modification or replacement of testing thresholds and P-values with confidence intervals, Bayes fac...

    Authors: Zad Rafi and Sander Greenland

    Citation: BMC Medical Research Methodology 2020 20:244

    Content type: Technical advance

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  22. The early warning model of infectious diseases plays a key role in prevention and control. This study aims to using seasonal autoregressive fractionally integrated moving average (SARFIMA) model to predict the...

    Authors: Chang Qi, Dandan Zhang, Yuchen Zhu, Lili Liu, Chunyu Li, Zhiqiang Wang and Xiujun Li

    Citation: BMC Medical Research Methodology 2020 20:243

    Content type: Research article

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  23. There is consensus that health services commissioning and clinical practice should be driven by scientific evidence. However, workload pressures, accessibility of peer reviewed publications and skills to find,...

    Authors: Joanna K. Anderson, Emma Howarth, Maris Vainre, Ayla Humphrey, Peter B. Jones and Tamsin J. Ford

    Citation: BMC Medical Research Methodology 2020 20:242

    Content type: Research article

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  24. The objectives of the present study were to evaluate the performance of a time-to-event data reconstruction method, to assess the bias and efficiency of unanchored matching-adjusted indirect comparison (MAIC) ...

    Authors: Yawen Jiang and Weiyi Ni

    Citation: BMC Medical Research Methodology 2020 20:241

    Content type: Research article

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  25. Bias in randomized controlled trials (RCTs) can lead to underestimation or overestimation of the true effects of interventions. Surgical RCTs may suffer from the risk of bias (RoB) that is avoidable in trials ...

    Authors: Ognjen Barcot, Matija Boric, Svjetlana Dosenovic, Marija Cavar, Antonia Jelicic Kadic, Tina Poklepovic Pericic, Ivana Vukicevic, Ivana Vuka and Livia Puljak

    Citation: BMC Medical Research Methodology 2020 20:240

    Content type: Research article

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  26. A very large body of research documents relationships between self-reported Adverse Childhood Experiences (srACEs) and adult health outcomes. Despite multiple assessment tools that use the same or similar ques...

    Authors: Marianna D. LaNoue, Brandon J. George, Deborah L. Helitzer and Scott W. Keith

    Citation: BMC Medical Research Methodology 2020 20:239

    Content type: Research article

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  27. Very large cohorts that span an entire population raise new prospects for the conduct of multiple trials that speed up advances in prevention or treatment while reducing participant, financial and regulatory b...

    Authors: Melissa Wake, Yanhong Jessika Hu, Hayley Warren, Margie Danchin, Michael Fahey, Francesca Orsini, Maurizio Pacilli, Kirsten P. Perrett, Richard Saffery and Andrew Davidson

    Citation: BMC Medical Research Methodology 2020 20:238

    Content type: Technical advance

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  28. Evidence based medicine aims to integrate scientific evidence, clinical experience, and patient values and preferences. Individual health care professionals need to appraise the evidence from randomized trials...

    Authors: Hendrika J. Luijendijk, Matthew J. Page, Huibert Burger and Xander Koolman

    Citation: BMC Medical Research Methodology 2020 20:237

    Content type: Technical advance

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  29. The population attributable fraction (PAF) is the fraction of disease cases in a sample that can be attributed to an exposure. Estimating the PAF often involves the estimation of the probability of having the ...

    Authors: Wei Wang, Dylan S. Small and Michael O. Harhay

    Citation: BMC Medical Research Methodology 2020 20:236

    Content type: Technical advance

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  30. Usability testing of medical devices are mandatory for market access. The testings’ goal is to identify usability problems that could cause harm to the user or limit the device’s effectiveness. In practice, hu...

    Authors: Vincent Vandewalle, Alexandre Caron, Coralie Delettrez, Renaud Périchon, Sylvia Pelayo, Alain Duhamel and Benoit Dervaux

    Citation: BMC Medical Research Methodology 2020 20:234

    Content type: Technical advance

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  31. Contact tracing data of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is used to estimate basic epidemiological parameters. Contact tracing data could also be potentially used for assessin...

    Authors: Karikalan Nagarajan, Malaisamy Muniyandi, Bharathidasan Palani and Senthil Sellappan

    Citation: BMC Medical Research Methodology 2020 20:233

    Content type: Research article

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  32. Psychiatric disorders may occur as a single episode or be persistent and relapsing, sometimes leading to suicidal behaviours. The exact causes of psychiatric disorders are hard to determine but easy access to ...

    Authors: Sharmin Sharker, Lloyd Balbuena, Gene Marcoux and Cindy Xin Feng

    Citation: BMC Medical Research Methodology 2020 20:232

    Content type: Research article

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  33. Emergency Departments (EDs) are a first point-of-contact for many youth with mental health and suicidality concerns and can serve as an effective recruitment source for randomized controlled trials (RCTs) of m...

    Authors: Matthew Tracey, Yaron Finkelstein, Reva Schachter, Kristin Cleverley, Suneeta Monga, Melanie Barwick, Peter Szatmari, Myla E. Moretti, Andrew Willan, Joanna Henderson and Daphne J. Korczak

    Citation: BMC Medical Research Methodology 2020 20:231

    Content type: Research article

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  34. Master of public health (MPH) plays an important role in Chinese medical education, and the dissertations is an important part of MPH education. In MPH dissertations, most are observational studies. Compared w...

    Authors: Shuangyang Dai, Xiaobin Zhou, Hong Xu, Beibei Li and Jingao Zhang

    Citation: BMC Medical Research Methodology 2020 20:230

    Content type: Research article

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  35. Defining incident cases has always been a challenging issue for researchers working with routine data. Lookback periods should enable researchers to identify and exclude recurrent cases and increase the accura...

    Authors: Jelena Epping, Siegfried Geyer and Juliane Tetzlaff

    Citation: BMC Medical Research Methodology 2020 20:229

    Content type: Research article

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  36. COVID-19, the disease caused by the highly infectious and transmissible coronavirus SARS-CoV-2, has quickly become a morbid global pandemic. Although the impact of SARS-CoV-2 infection in children is less clin...

    Authors: Rosiane Lima, Elizabeth F. Gootkind, Denis De la Flor, Laura J. Yockey, Evan A. Bordt, Paolo D’Avino, Shen Ning, Katerina Heath, Katherine Harding, Jaclyn Zois, Grace Park, Margot Hardcastle, Kathleen A. Grinke, Sheila Grimmel, Susan P. Davidson, Pamela J. Forde…

    Citation: BMC Medical Research Methodology 2020 20:228

    Content type: Research article

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  37. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Junhao Liu, Jo Wick, Renee’ H. Martin, Caitlyn Meinzer, Dooti Roy and Byron Gajewski

    Citation: BMC Medical Research Methodology 2020 20:227

    Content type: Correction

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    The original article was published in BMC Medical Research Methodology 2020 20:211

  38. Methodological studies – studies that evaluate the design, analysis or reporting of other research-related reports – play an important role in health research. They help to highlight issues in the conduct of r...

    Authors: Lawrence Mbuagbaw, Daeria O. Lawson, Livia Puljak, David B. Allison and Lehana Thabane

    Citation: BMC Medical Research Methodology 2020 20:226

    Content type: Commentary

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  39. Claims databases are generally considered inadequate for obesity research due to suboptimal capture of body mass index (BMI) measurements. This might not be true for bariatric surgery because of reimbursement ...

    Authors: Xiaojuan Li, Kristina H. Lewis, Katherine Callaway, J. Frank Wharam and Sengwee Toh

    Citation: BMC Medical Research Methodology 2020 20:225

    Content type: Research article

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  40. Clinical Trials (CTs) help in testing and validating the safety and efficacy of newly discovered drugs on specific patient population cohorts. However, these trials usually experience many challenges, such as ...

    Authors: Ilhaam A. Omar, Raja Jayaraman, Khaled Salah, Mecit Can Emre Simsekler, Ibrar Yaqoob and Samer Ellahham

    Citation: BMC Medical Research Methodology 2020 20:224

    Content type: Technical advance

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  41. Health-related quality of life (HRQoL) has become a major endpoint to assess the clinical benefit of new therapeutic strategies in oncology clinical trials. Typically, HRQoL outcomes are analyzed using linear ...

    Authors: B. Cuer, C. Mollevi, A. Anota, E. Charton, B. Juzyna, T. Conroy and C. Touraine

    Citation: BMC Medical Research Methodology 2020 20:223

    Content type: Research article

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  42. Parallel intervention studies involving volunteers usually require a procedure to allocate the subjects to study-arms. Statistical models to evaluate the different outcomes of the study-arms will include study...

    Authors: Eric D. Schoen and Suzan Wopereis

    Citation: BMC Medical Research Methodology 2020 20:222

    Content type: Technical advance

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  43. Event-related potentials (ERP) data are widely used in brain studies that measure brain responses to specific stimuli using electroencephalogram (EEG) with multiple electrodes. Previous ERP data analyses haven...

    Authors: Ye Lin, Jianhui Zhou, Swapna Kumar, Wanze Xie, Sarah K. G. Jensen, Rashidul Haque, Charles A. Nelson, William A. Petri Jr and Jennie Z. Ma

    Citation: BMC Medical Research Methodology 2020 20:221

    Content type: Research article

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  44. Because of unknown features of the COVID-19 and the complexity of the population affected, standard clinical trial designs on treatments may not be optimal in such patients. We propose two independent clinical...

    Authors: Shesh N. Rai, Chen Qian, Jianmin Pan, Anand Seth, Deo Kumar Srivastava and Aruni Bhatnagar

    Citation: BMC Medical Research Methodology 2020 20:220

    Content type: Research article

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  45. Evaluating a candidate marker or developing a model for predicting risk of future conditions is one of the major goals in medicine. However, model development and assessment for a time-to-event outcome may be ...

    Authors: Rajib Dey, Giada Sebastiani and Paramita Saha-Chaudhuri

    Citation: BMC Medical Research Methodology 2020 20:219

    Content type: Technical advance

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  46. The data from immuno-oncology (IO) therapy trials often show delayed effects, cure rate, crossing hazards, or some mixture of these phenomena. Thus, the proportional hazards (PH) assumption is often violated s...

    Authors: Jason J. Z. Liao, G. Frank Liu and Wen-Chi Wu

    Citation: BMC Medical Research Methodology 2020 20:218

    Content type: Technical advance

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  47. Realist methodologies are increasingly being used to evaluate complex interventions in health and social care. Programme theory (ideas and assumptions of how a particular intervention works) development is the...

    Authors: Susanne Coleman, Judy M. Wright, Jane Nixon, Lisette Schoonhoven, Maureen Twiddy and Joanne Greenhalgh

    Citation: BMC Medical Research Methodology 2020 20:217

    Content type: Research article

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  48. This paper reports the construction and use of a specific method for qualitative medical research: The Inductive Process to Analyze the Structure of lived Experience (IPSE), an inductive and phenomenological appr...

    Authors: Jordan Sibeoni, Laurence Verneuil, Emilie Manolios and Anne Révah-Levy

    Citation: BMC Medical Research Methodology 2020 20:216

    Content type: Technical advance

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  49. Collection of biospecimens is a critical first step to understanding the impact of COVID-19 on pregnant women and newborns - vulnerable populations that are challenging to enroll and at risk of exclusion from ...

    Authors: Lydia L. Shook, Jessica E. Shui, Adeline A. Boatin, Samantha Devane, Natalie Croul, Lael M. Yonker, Juan D. Matute, Rosiane S. Lima, Muriel Schwinn, Dana Cvrk, Laurel Gardner, Robin Azevedo, Suzanne Stanton, Evan A. Bordt, Laura J. Yockey, Alessio Fasano…

    Citation: BMC Medical Research Methodology 2020 20:215

    Content type: Research article

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