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  1. Qualitative research networks (QRNs) bring together researchers from diverse contexts working on multi-country studies. The networks may themselves form a consortium or may contribute to a wider research agend...

    Authors: Lot Nyirenda, Meghan Bruce Kumar, Sally Theobald, Malabika Sarker, Musonda Simwinga, Moses Kumwenda, Cheryl Johnson, Karin Hatzold, Elizabeth L. Corbett, Euphemia Sibanda and Miriam Taegtmeyer

    Citation: BMC Medical Research Methodology 2020 20:13

    Content type: Technical advance

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  2. Integrated care is an increasingly important principle for organising healthcare. Integrated care models show promise in reducing resource wastage and service fragmentation whilst improving the accessibility, ...

    Authors: Raechel A. Damarell, Suzanne Lewis, Camilla Trenerry and Jennifer J. Tieman

    Citation: BMC Medical Research Methodology 2020 20:12

    Content type: Research article

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  3. Systematic reviews are a key input to health and social welfare decisions. Studies included in systematic reviews often vary with respect to contextual factors that may impact on how transferable review findin...

    Authors: Heather Munthe-Kaas, Heid Nøkleby, Simon Lewin and Claire Glenton

    Citation: BMC Medical Research Methodology 2020 20:11

    Content type: Research article

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  4. Randomised trial protocols may incorporate interim analyses, with the potential to stop the study for futility if early data show insufficient promise of a treatment benefit. Previously, we have shown that thi...

    Authors: S. D. Walter, H. Han, G. H. Guyatt, D. Bassler, N. Bhatnagar, V. Gloy, S. Schandelmaier and M. Briel

    Citation: BMC Medical Research Methodology 2020 20:10

    Content type: Research article

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  5. Drug safety in children is a major concern; however, there is still a lack of methods for quantitatively measuring, let alone to improving, drug safety in children under different clinical conditions. To asses...

    Authors: Gang Yu, Xian Zeng, Shaoqing Ni, Zheng Jia, Weihong Chen, Xudong Lu, Jiye An, Huilong Duan, Qiang Shu and Haomin Li

    Citation: BMC Medical Research Methodology 2020 20:9

    Content type: Research article

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  6. The design and execution of measurement in quality improvement (QI) initiatives is often poor. Better guidance on “what good looks like” might help to mitigate some of the problems. We report a consensus-build...

    Authors: Thomas Woodcock, Yewande Adeleke, Christine Goeschel, Peter Pronovost and Mary Dixon-Woods

    Citation: BMC Medical Research Methodology 2020 20:8

    Content type: Research article

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  7. Systematic reviews are vital to the pursuit of evidence-based medicine within healthcare. Screening titles and abstracts (T&Ab) for inclusion in a systematic review is an intensive, and often collaborative, st...

    Authors: Hannah Harrison, Simon J. Griffin, Isla Kuhn and Juliet A. Usher-Smith

    Citation: BMC Medical Research Methodology 2020 20:7

    Content type: Research article

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  8. This study examined the criterion validity of the online Active Australia Survey, using accelerometry as the criterion, and whether self-report bias was related to level of activity, age, sex, education, body ...

    Authors: Rachel G. Curtis, Timothy Olds, Ronald Plotnikoff, Corneel Vandelanotte, Sarah Edney, Jillian Ryan and Carol Maher

    Citation: BMC Medical Research Methodology 2020 20:6

    Content type: Research article

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  9. Multicenter studies from Europe and the United States have developed specifically standardized questionnaires for assessing and comparing sedentary behavior, but they cannot be directly applied for South Ameri...

    Authors: Augusto César Ferreira De Moraes, Marcus Vinícius Nascimento-Ferreira, Claudia Lucia de Moraes Forjaz, Juan Carlos Aristizabal, Leticia Azzaretti, Walter Viana Nascimento Junior, Maria L. Miguel-Berges, Estela Skapino, Carlos Delgado, Luis A. Moreno and Heráclito Barbosa Carvalho

    Citation: BMC Medical Research Methodology 2020 20:5

    Content type: Research article

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  10. There is a growing interest in the use of Bayesian adaptive designs in late-phase clinical trials. This includes the use of stopping rules based on Bayesian analyses in which the frequentist type I error rate ...

    Authors: Nigel Stallard, Susan Todd, Elizabeth G. Ryan and Simon Gates

    Citation: BMC Medical Research Methodology 2020 20:4

    Content type: Research Article

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  11. Researchers and clinicians use text messages to collect data with the advantage of real time capture when compared with standard data collection methods. This article reviews project setup and management for s...

    Authors: Noa’a Shimoni, Siripanth Nippita and Paula M. Castaño

    Citation: BMC Medical Research Methodology 2020 20:2

    Content type: Technical advance

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  12. Clinical research and medical practice can be advanced through the prediction of an individual’s health state, trajectory, and responses to treatments. However, the majority of current clinical risk prediction...

    Authors: Shannon Wongvibulsin, Katherine C. Wu and Scott L. Zeger

    Citation: BMC Medical Research Methodology 2019 20:1

    Content type: Technical Advance

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  13. Aboriginal people are known to be under-recorded in routinely collected datasets in Australia. This study examined methods for enhancing the reporting of cancer incidence among Aboriginal people using linked d...

    Authors: Hanna E. Tervonen, Stuart Purdie and Nicola Creighton

    Citation: BMC Medical Research Methodology 2019 19:245

    Content type: Research article

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  14. Cohort studies are pivotal in understanding the natural history, and to thereby determine the incidence of a disease. The conduct of large-scale community-based cohort studies is challenging with reference to ...

    Authors: Kulandaipalayam Natarajan Sindhu, Manikandan Srinivasan, Sathyapriya Subramaniam, Anita Shirley David, Venkata Raghava Mohan, Jacob John and Gagandeep Kang

    Citation: BMC Medical Research Methodology 2019 19:244

    Content type: Research article

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  15. Research priority setting with stakeholders can help direct the limited resources for health research toward priority areas of need. Ensuring transparency of the priority setting process can strengthen legitim...

    Authors: Allison Tong, Anneliese Synnot, Sally Crowe, Sophie Hill, Andrea Matus, Nicole Scholes-Robertson, Sandy Oliver, Katherine Cowan, Mona Nasser, Soumyadeep Bhaumik, Talia Gutman, Amanda Baumgart and Jonathan C. Craig

    Citation: BMC Medical Research Methodology 2019 19:243

    Content type: Research article

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  16. This study aimed to address the current limitations of the use of composite endpoints in orthopaedic trauma research by quantifying the relative importance of clinical outcomes common to orthopaedic trauma pat...

    Authors: Ugochukwu N. Udogwu, Andrea Howe, Katherine Frey, Marckenley Isaac, Daniel Connelly, Dimitrius Marinos, Mitchell Baker, Renan C. Castillo, Gerard P. Slobogean, Robert V. O’Toole and Nathan N. O’Hara

    Citation: BMC Medical Research Methodology 2019 19:242

    Content type: Research article

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  17. Subsequent to a three-month pilot phase, recruiting patients for the newly established BFCC (Baltic Fracture Competence Centre) transnational fracture registry, a validation of the data quality needed to be ca...

    Authors: Jasper Frese, Annalice Gode, Gerhard Heinrichs, Armin Will and Arndt-Peter Schulz

    Citation: BMC Medical Research Methodology 2019 19:241

    Content type: Research article

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  18. Following publication of the original article [1], the authors reported a change in the ‘Competing interests’ section as described below.

    Authors: Bradley C. Johnston, Pablo Alonso-Coello, Malgorzata M. Bala, Dena Zeraatkar, Montserrat Rabassa, Claudia Valli, Catherine Marshall, Regina El Dib, Robin W. M. Vernooij, Per O. Vandvik and Gordon H. Guyatt

    Citation: BMC Medical Research Methodology 2019 19:240

    Content type: Correction

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    The original article was published in BMC Medical Research Methodology 2018 18:162

  19. The Multiphase Optimization Strategy (MOST) is designed to maximize the impact of clinical healthcare interventions, which are typically multicomponent and increasingly complex. MOST often relies on factorial ...

    Authors: Jocelyn Kuhn, Radley Christopher Sheldrick, Sarabeth Broder-Fingert, Andrea Chu, Lisa Fortuna, Megan Jordan, Dana Rubin and Emily Feinberg

    Citation: BMC Medical Research Methodology 2019 19:239

    Content type: Technical advance

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  20. Trainee research collaboratives (TRCs) have pioneered high quality, prospective ‘snap-shot’ surgical cohort studies in the UK. Outcomes After Kidney injury in Surgery (OAKS) was the first TRC cohort study to a...

    Authors: Dmitri Nepogodiev

    Citation: BMC Medical Research Methodology 2019 19:237

    Content type: Research article

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  21. Falls are common among older people, and General Practitioners (GPs) could play an important role in implementing strategies to manage fall risk. Despite this, fall prevention is not a routine activity in gene...

    Authors: Amy C. W. Tan, Lindy Clemson, Lynette Mackenzie, Catherine Sherrington, Chris Roberts, Anne Tiedemann, Constance D. Pond, Fiona White and Judy M. Simpson

    Citation: BMC Medical Research Methodology 2019 19:236

    Content type: Research article

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  22. Consent to link survey data with health-related administrative datasets is increasingly being sought but little is known about the influence of recruiting via online technologies on participants’ consents. The...

    Authors: Anna Graves, Deirdre McLaughlin, Janni Leung and Jennifer Powers

    Citation: BMC Medical Research Methodology 2019 19:235

    Content type: Research article

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  23. All clinical research benefits from transparency and validity. Transparency and validity of studies may increase by prospective registration of protocols and by publication of statistical analysis plans (SAPs)...

    Authors: Bart Hiemstra, Frederik Keus, Jørn Wetterslev, Christian Gluud and Iwan C. C. van der Horst

    Citation: BMC Medical Research Methodology 2019 19:233

    Content type: Debate

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  24. Verbal autopsy (VA) is increasingly being considered as a cost-effective method to improve cause of death information in countries with low quality vital registration. VA algorithms that use empirical data hav...

    Authors: Hafizur Rahman Chowdhury, Abraham D. Flaxman, Jonathan C. Joseph, Riley H. Hazard, Nurul Alam, Ian Douglas Riley and Alan D. Lopez

    Citation: BMC Medical Research Methodology 2019 19:232

    Content type: Research article

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  25. In low-income settings, key outcomes such as biomarkers or clinical assessments are often missing for a substantial proportion of the study population. The aim of this study was to assess the extent to which H...

    Authors: Siaka Koné, Bassirou Bonfoh, Daouda Dao, Inza Koné and Günther Fink

    Citation: BMC Medical Research Methodology 2019 19:231

    Content type: Technical advance

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  26. Questionnaires are valuable data collection instruments in public health research, and can serve to pre-screen respondents for suitability in future studies. Survey non-response leads to reduced effective samp...

    Authors: Michael G. Smith, Maryam Witte, Sarah Rocha and Mathias Basner

    Citation: BMC Medical Research Methodology 2019 19:230

    Content type: Research article

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  27. Patient-Reported Outcome Measures (PROMs) have been proposed for benchmarking health care quality across hospitals, which requires extensive case-mix adjustment. The current study’s aim was to develop and comp...

    Authors: Arvind Oemrawsingh, Nikki van Leeuwen, Esmee Venema, Martien Limburg, Frank-Erik de Leeuw, Markus P. Wijffels, Aafke J. de Groot, Pieter H. E. Hilkens, Jan A. Hazelzet, Diederik W. J. Dippel, Carla H. Bakker, Helene R. Voogdt-Pruis and Hester F. Lingsma

    Citation: BMC Medical Research Methodology 2019 19:229

    Content type: Research article

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  28. Multi-center studies can generate robust and generalizable evidence, but privacy considerations and legal restrictions often make it challenging or impossible to pool individual-level data across data-contribu...

    Authors: Di Shu, Jessica G. Young and Sengwee Toh

    Citation: BMC Medical Research Methodology 2019 19:228

    Content type: Research article

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  29. Our population is ageing and in 2050 more than one out of five people will be 60 years or older; 80% of whom will be living in a low-and-middle income country. Living longer does not entail living healthier; h...

    Authors: Christina Daskalopoulou, Kia-Chong Chua, Artemis Koukounari, Francisco Félix Caballero, Martin Prince and A. Matthew Prina

    Citation: BMC Medical Research Methodology 2019 19:226

    Content type: Research article

    Published on:

    The Research article to this article has been published in BMC Medical Research Methodology 2019 19:225

  30. In the absence of a consensus on definition and measurement of healthy ageing, we created a healthy ageing index tallying with the functional ability framework provided by the World Health Organization. To cre...

    Authors: Christina Daskalopoulou, Martin Prince, Artemis Koukounari, Josep Maria Haro, Demosthenes B. Panagiotakos and A. Matthew Prina

    Citation: BMC Medical Research Methodology 2019 19:225

    Content type: Research article

    Published on:

    The Research article to this article has been published in BMC Medical Research Methodology 2019 19:226

  31. Goal Attainment Scaling (GAS) is an instrument that is intended to evaluate the effect of an intervention by assessing change in daily life activities on an individual basis. However, GAS has not been validate...

    Authors: C. M. W. Gaasterland, M. C. Jansen van der Weide, K. C. B. Roes and J. H. van der Lee

    Citation: BMC Medical Research Methodology 2019 19:227

    Content type: Research article

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  32. In the original publication of this article [1] the author Marc Du Bois was omitted. In this correction article the author and the corresponding details are provided. The publisher apologizes to the readers an...

    Authors: Kaat Goorts, Charlotte Vanovenberghe, Charlotte Lambreghts, Eline Bruneel, Dorina Rusu, Marc Du Bois, Sofie Vandenbroeck and Lode Godderis

    Citation: BMC Medical Research Methodology 2019 19:224

    Content type: Correction

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    The original article was published in BMC Medical Research Methodology 2019 19:205

  33. Attrition due to death and non-attendance are common sources of bias in studies of age-related diseases. A simulation study is presented to compare two methods for estimating the survivor average causal effect...

    Authors: Myra B. McGuinness, Jessica Kasza, Amalia Karahalios, Robyn H. Guymer, Robert P. Finger and Julie A. Simpson

    Citation: BMC Medical Research Methodology 2019 19:223

    Content type: Research article

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  34. The recent progress in medical research generates an increasing interest in the use of longitudinal biomarkers for characterizing the occurrence of an outcome. The present work is motivated by a study, where t...

    Authors: Maeregu W. Arisido, Laura Antolini, Davide P. Bernasconi, Maria G. Valsecchi and Paola Rebora

    Citation: BMC Medical Research Methodology 2019 19:222

    Content type: Research Article

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  35. To assess cross-cultural validity between Dutch and English versions of the FVQ_CYP, a patient-reported outcome measure developed in the United Kingdom (UK) for children and adolescents with (severe) visual im...

    Authors: Ellen B. M. Elsman, Valerija Tadić, Carel F. W. Peeters, Ger H. M. B. van Rens, Jugnoo S. Rahi and Ruth M. A. van Nispen

    Citation: BMC Medical Research Methodology 2019 19:221

    Content type: Research article

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  36. Exercise is an effective therapeutic intervention for cancer survivors. Concerns about the completeness of reporting of exercise interventions have been raised in the literature, but without any formal analysi...

    Authors: Jose Francisco Meneses-Echavez, Indira Rodriguez-Prieto, Mark Elkins, Javier Martínez-Torres, Lien Nguyen and Julia Bidonde

    Citation: BMC Medical Research Methodology 2019 19:220

    Content type: Research article

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  37. Within qualitative research in-person interviews have the reputation for being the highest standard of interviewer-participant encounter. However, there are other approaches to interviewing such as telephone a...

    Authors: Matthew Krouwel, Kate Jolly and Sheila Greenfield

    Citation: BMC Medical Research Methodology 2019 19:219

    Content type: Research article

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  38. Until recently a typical rule that has often been used for the endorsement of new medications by the Food and Drug Administration has been the existence of at least two statistically significant clinical trial...

    Authors: Don van Ravenzwaaij and John P. A. Ioannidis

    Citation: BMC Medical Research Methodology 2019 19:218

    Content type: Technical advance

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  39. Continuous monitoring of surgical outcomes after joint replacement is needed to detect which brands’ components have a higher than expected failure rate and are therefore no longer recommended to be used in su...

    Authors: Alexander Begun, Elena Kulinskaya and Alexander J MacGregor

    Citation: BMC Medical Research Methodology 2019 19:217

    Content type: Research Article

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  40. Antiretroviral therapy (ART) has significantly reduced HIV-related morbidity and mortality. However, therapeutic benefit of ART is often limited by delayed drug-associated toxicity. Nucleoside reverse transcri...

    Authors: Jong Soo Lee, Elijah Paintsil, Vivek Gopalakrishnan and Musie Ghebremichael

    Citation: BMC Medical Research Methodology 2019 19:216

    Content type: Research article

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  41. Antimalarial clinical efficacy studies for uncomplicated Plasmodium falciparum malaria frequently encounter situations in which molecular genotyping is unable to discriminate between parasitic recurrence, either ...

    Authors: Prabin Dahal, Kasia Stepniewska, Philippe J. Guerin, Umberto D’Alessandro, Ric N. Price and Julie A. Simpson

    Citation: BMC Medical Research Methodology 2019 19:215

    Content type: Research article

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  42. Due to an error introduced during copyediting of this article [1], following corrections need to be made.

    Authors: R. G. Singotani, F. Karapinar, C. Brouwers, C. Wagner and M. C. de Bruijne

    Citation: BMC Medical Research Methodology 2019 19:214

    Content type: Correction

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    The original article was published in BMC Medical Research Methodology 2019 19:189

  43. We recently introduced a system of partial differential equations (PDEs) to model the prevalence of chronic diseases with a possibly prolonged state of asymptomatic, undiagnosed disease preceding a diagnosis. ...

    Authors: Ralph Brinks, Sophie Kaufmann, Annika Hoyer, Edward W Gregg and Jürgen Saal

    Citation: BMC Medical Research Methodology 2019 19:213

    Content type: Research Article

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  44. Many population health surveys consist of a mixed-mode design that includes a face-to-face (F2F) interview followed by a paper-and-pencil (P&P) self-administered questionnaire (SAQ) for the sensitive topics. I...

    Authors: Elise Braekman, Sabine Drieskens, Rana Charafeddine, Stefaan Demarest, Finaba Berete, Lydia Gisle, Jean Tafforeau, Johan Van der Heyden and Guido Van Hal

    Citation: BMC Medical Research Methodology 2019 19:212

    Content type: Research article

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  45. Engaging those who influence, administer and/or who are active users (“knowledge users”) of health care systems, as co-producers of health research, can help to ensure that research products will better addres...

    Authors: Janet E. Jull, Laurie Davidson, Rachel Dungan, Tram Nguyen, Krista P. Woodward and Ian D. Graham

    Citation: BMC Medical Research Methodology 2019 19:211

    Content type: Research article

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  46. Large and complex population-based cancer data are becoming broadly available, thanks to purposeful linkage between cancer registry data and health electronic records. Aiming at understanding the explanatory p...

    Authors: Camille Maringe, Aurélien Belot, Francisco Javier Rubio and Bernard Rachet

    Citation: BMC Medical Research Methodology 2019 19:210

    Content type: Research article

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  47. Central cancer registries are often used to survey population-based samples of cancer survivors. These surveys are typically administered via paper or telephone. In most populations, web surveys obtain much lo...

    Authors: Morgan M. Millar, Joanne W. Elena, Lisa Gallicchio, Sandra L. Edwards, Marjorie E. Carter, Kimberly A. Herget and Carol Sweeney

    Citation: BMC Medical Research Methodology 2019 19:208

    Content type: Research article

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