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Table 1 Power to detect heterogeneity between the two components of a composite outcome by degree of heterogeneity (equal balance among components) with OR1 = 0.65

From: Testing for heterogeneity among the components of a binary composite outcome in a clinical trial

Hetero- geneity OR2 Composite Overall OR Weighted DD Weighted RS Independent Random Effects GEE
None 0.65 0.65 3.0 3.2 3.9 4.0 5.3
  0.70 0.67 5.1 5.2 6.3 6.4 8.1
Low 0.75 0.70 13.1 13.2 15.6 15.6 17.9
  0.80 0.72 26.0 26.2 29.5 29.8 33.4
Moderate 0.85 0.75 42.7 42.9 46.9 46.9 51.1
  0.90 0.78 60.2 60.3 63.9 64.0 67.8
  0.95 0.80 74.6 74.6 77.7 77.8 80.7
  1.00 0.83 85.3 85.4 87.6 87.5 89.9
High 1.05 0.85 92.2 92.3 93.8 93.8 95.0
  1.10 0.88 96.6 96.7 97.4 97.4 97.8
  1.15 0.91 98.4 98.4 98.8 98.8 99.0
  1.20 0.93 99.4 99.4 99.6 99.5 99.7