Table 1 Power to detect heterogeneity between the two components of a composite outcome by degree of heterogeneity (equal balance among components) with OR1 = 0.65
From: Testing for heterogeneity among the components of a binary composite outcome in a clinical trial
Hetero- geneity | OR2 | Composite Overall OR | Weighted DD | Weighted RS | Independent | Random Effects | GEE |
|---|---|---|---|---|---|---|---|
None | 0.65 | 0.65 | 3.0 | 3.2 | 3.9 | 4.0 | 5.3 |
| Â | 0.70 | 0.67 | 5.1 | 5.2 | 6.3 | 6.4 | 8.1 |
Low | 0.75 | 0.70 | 13.1 | 13.2 | 15.6 | 15.6 | 17.9 |
| Â | 0.80 | 0.72 | 26.0 | 26.2 | 29.5 | 29.8 | 33.4 |
Moderate | 0.85 | 0.75 | 42.7 | 42.9 | 46.9 | 46.9 | 51.1 |
| Â | 0.90 | 0.78 | 60.2 | 60.3 | 63.9 | 64.0 | 67.8 |
| Â | 0.95 | 0.80 | 74.6 | 74.6 | 77.7 | 77.8 | 80.7 |
| Â | 1.00 | 0.83 | 85.3 | 85.4 | 87.6 | 87.5 | 89.9 |
High | 1.05 | 0.85 | 92.2 | 92.3 | 93.8 | 93.8 | 95.0 |
| Â | 1.10 | 0.88 | 96.6 | 96.7 | 97.4 | 97.4 | 97.8 |
| Â | 1.15 | 0.91 | 98.4 | 98.4 | 98.8 | 98.8 | 99.0 |
| Â | 1.20 | 0.93 | 99.4 | 99.4 | 99.6 | 99.5 | 99.7 |