Table 2 Power for detecting heterogeneity of treatment effect by varying degrees of balance among the components of the composite for a moderate heterogeneity pattern OR1, OR2= (0.65, 1.00) and ratio (p1:p2) of occurrence of components 1 and 2.
From: Testing for heterogeneity among the components of a binary composite outcome in a clinical trial
Balance (p1:p2) | Weighted DD | Weighted RS | Independent | Random Effects | GEE |
|---|---|---|---|---|---|
1:1 | 85.3 | 85.8 | 88.1 | 88.2 | 90.0 |
1:3 | 77.0 | 77.1 | 75.4 | 75.4 | 78.7 |
1:5 | 65.0 | 65.0 | 59.4 | 59.4 | 62.8 |
3:1 | 79.1 | 79.1 | 79.5 | 79.9 | 82.3 |
5:1 | 70.3 | 70.3 | 68.2 | 68.6 | 71.1 |