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Table 8 Properties of point and 95% interval estimates calculated from Models A - E based on 1000 simulated datasets in scenario 9 - unbalanced, 46 centres, same centre composition as the COMPETE II trial.

From: Comparing methods to estimate treatment effects on a continuous outcome in multicentre randomized controlled trials: A simulation study

  SCENARIO 9
Model Mean effect
(SD)
Ave.
SE
MSE Cover.
of CI
Power
ICC = 0.125
A 1.254
(0.236)
0.249 0.056 0.965 0.999
B 1.253
(0.240)
0.236 0.058 0.952 1
C 1.253
(0.237)
0.235 0.056 0.949 0.999
D 1.253
(0.237)
0.230 0.056 0.944 0.999
E-1 1.256
(0.405)
0.207 0.165 0.787 0.991
E-2 1.257
(0.270)
0.261 0.073 0.935 0.995
  1. SD: empirical standard deviation; Ave. SE: average estimated SE; MSE: mean squared error; Cover. of CI: coverage proportion of 95% confidence interval; ICC: intraclass (intracentre) correlation