|
Sample size
|
1
|
500 patients, 250 in each treatment arm
|
|
Weibull shape parameter γ
|
1
|
0.5, to represent mortality rate decreasing over time
|
|
Weibull scale parameter λ
|
1
|
1.33, chosen such that 90% of patients have died after 3 years of follow-up
|
|
Probability of patient having 'good' prognosis
|
2
|
30% or 75%
|
|
Difference in survival between 'good' and 'poor' Prognosis groups
|
2
|
Survival times of 'good' prognosis group multiplied by a factor of either 1.2 or 3
|
|
Probability of switching treatment dependent on prognosis group
|
2
|
10% ('good' prognosis) and 25% ('poor' prognosis) or 50% ('good' prognosis) and 75% ('poor' prognosis)
|
|
Switching time
|
1
|
Generated from a Uniform distribution
|
|
Initial treatment effect
|
2
|
Hazard ratio of 0.9 or 0.7
|
