Modifiable factors | Non-modifiable Factors | ||
---|---|---|---|
Risk | Protective | Risk | Protective |
Burdensome data collection at recruiting sites | Support from a methods centre, clinical trials unit, or contract research organization | Placebo control | Active treatment as control |
No professional staff at recruiting centres to manage the trial | Paid local staff at recruiting centres, dedicated central trial coordinator, patient involvement in trial planning and/or conduct | No external funding | Externally funded or fully Industry sponsored |
No projection of recruitment rates | Projection of patient recruitment based on e.g. pilot trial applying the full protocol or other checks for eligible patient volume | Long duration of follow-up | Short duration of follow-up / High community interest in research topic (e.g. new technology or new treatment) |
No consideration of recruitment strategies | Consideration of recruitment support strategies (e.g. regular visits/audits by PI; specific training held for recruiting staff; regular progress reports; posters and information leaflets etc.) | No research network, low trial experience | Experienced PI/steering committee/network of recruiting centres for RCTs |
Single centre trial | Multicentre trial | Equivalence/non-inferiority design | Intervention only available through trial participation |
Low motivation for recruiting sites | Financial incentives for recruiting staff and participants | Critically ill or paediatric patients as target population | Trial experience with certain vulnerable trial populations |