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Table 2 Model parameters for fixed and random effects two-dimensional (Weibull) network meta-analysis models with and without treatment-by-covariate interaction

From: Meta-regression models to address heterogeneity and inconsistency in network meta-analysis of survival outcomes

  Fixed effects model Random effects model (model 1) Random effects model with treatment specific covariate interaction* (model 2) Random effects model with constant treatment-by-covariate interaction* (model 3)
  Median of posterior distribution 95% Credible Interval Median of posterior distribution 95% Credible Interval Median of posterior distribution 95% Credible Interval Median of posterior distribution 95% Credible Interval
Pooled estimate for difference in scale β 0
 DTIC + IFN vs. DTIC (d 0AB ) −0.16 (−0.63; 0.33) −0.22 (−0.76; 0.23) −0.04 (−0.54; 0.47) −0.18 (−0.58; 0.39)
 DTIC + non-IFN vs. DTIC (d 0AC ) −0.07 (−0.46; 0.34) −0.19 (−0.65; 0.30) −0.16 (−0.66; 0.32) −0.10 (−0.51; 0.35)
 non-DTIC vs. DTIC (d 0AD ) −0.27 (−0.63; 0.13) −0.30 (−0.88; 0.24) −0.17 (−1.40; 1.11) −0.43 (−1.12; 0.06)
Pooled estimate for difference in shape β 1
 DTIC + IFN vs. DTIC (d 1AB ) 0.13 (−0.08; 0.33) 0.14 (−0.04; 0.34) 0.12 (−0.07; 0.30) 0.16 (−0.04; 0.30)
 DTIC + non-IFN vs. DTIC (d 1AC ) −0.06 (−0.23; 0.11) −0.02 (−0.19; 0.15) −0.04 (−0.21; 0.13) −0.05 (−0.19; 0.10)
 non-DTIC vs. DTIC (d 1AD ) 0.04 (−0.17; 0.23) 0.06 (−0.15; 0.27) 0.09 (−0.11; 0.29) 0.03 (−0.16; 0.21)
Estimate for covariate effect (βx)
 DTIC + IFN vs. DTIC (βx AB )      0.06 (−0.02; 0.16) 0.05 (−0.01; 0.12)
 DTIC + non-IFN vs. DTIC (βx AC )      0.06 (−0.05; 0.18) 0.05 (−0.01; 0.12)
 non-DTIC vs. DTIC (βx AD )      −0.02 (−0.21; 0.19) 0.05 (−0.01; 0.12)
Between study variance (heterogeneity) in scale    0.21 (0.02; 0.56) 0.19 (0.01; 0.52) 0.18 (0.01; 0.55)
  1. * Covariate value set at the average across studies.