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Table 5 Simulation results: proportion of replications where the maximum likelihood estimator is larger than the true value of the parameter for the exponential model

From: Estimating time-to-onset of adverse drug reactions from spontaneous reporting databases

λ

p

n

Naive estimator

TBE

0.05

0.25

100

100%

61.6%

  

500

100%

55.3%

0.05

0.50

100

100%

55.3%

  

500

100%

50.4%

0.05

0.80

100

100%

51.1%

  

500

100%

51.7%

1

0.25

100

100%

54.8%

  

500

100%

50.7%

1

0.50

100

100%

53.2%

  

500

100%

48.0%

1

0.80

100

100%

50.0%

  

500

100%

51.0%

  1. Calculations were made on the replications where there was no problem of maximization. Abbreviations : TBE truncation-based estimator.