From: Subgroup identification for treatment selection in biomarker adaptive design
Scenario | A | B | C | D | E | F | G | H |
---|---|---|---|---|---|---|---|---|
Predictive biomarkers | 10 | 15 | 20 | 10 | 10 | 10 | 10 | 15 |
Significances | 7.025 | 9.27 | 11.761 | 7.432 | 12.426 | 5.274 | 12.313 | 17.039 |
True positives | 4.147 | 6.443 | 8.865 | 4.487 | 9.495 | 2.202 | 9.267 | 14.002 |
DLDA Sensitivity | 0.598 | 0.651 | 0.694 | 0.626 | 0.979 | 0.507 | 0.985 | 0.99 |
Specificity | 0.991 | 0.993 | 0.993 | 0.995 | 0.999 | 0.94 | 0.983 | 0.99 |
PPV | 0.745 | 0.788 | 0.809 | 0.791 | 0.993 | 0.475 | 0.97 | 0.981 |
NPV | 0.958 | 0.963 | 0.968 | 0.96 | 0.998 | 0.946 | 0.992 | 0.995 |
Accuracy | 0.952 | 0.959 | 0.964 | 0.958 | 0.997 | 0.897 | 0.984 | 0.99 |
ASD (1,1) Sensitivity | 0.784 | 0.808 | 0.841 | 0.943 | 0.991 | 0.953 | 0.989 | 0.991 |
Specificity | 0.691 | 0.689 | 0.686 | 0.142 | 0.644 | 0.083 | 0.551 | 0.533 |
PPV | 0.253 | 0.256 | 0.268 | 0.112 | 0.283 | 0.104 | 0.51 | 0.5 |
NPV | 0.967 | 0.97 | 0.976 | 0.824 | 0.999 | 0.849 | 0.992 | 0.994 |
Accuracy | 0.7 | 0.7 | 0.702 | 0.222 | 0.679 | 0.169 | 0.682 | 0.671 |
ASD (1,2) Sensitivity | 0.635 | 0.683 | 0.723 | 0.831 | 0.982 | 0.807 | 0.977 | 0.982 |
Specificity | 0.931 | 0.927 | 0.923 | 0.357 | 0.899 | 0.284 | 0.853 | 0.838 |
PPV | 0.537 | 0.56 | 0.579 | 0.148 | 0.647 | 0.117 | 0.774 | 0.762 |
NPV | 0.959 | 0.964 | 0.97 | 0.903 | 0.998 | 0.904 | 0.991 | 0.993 |
Accuracy | 0.902 | 0.903 | 0.903 | 0.404 | 0.907 | 0.336 | 0.89 | 0.882 |
ASD (2,1) Sensitivity | 0.464 | 0.533 | 0.573 | 0.766 | 0.953 | 0.654 | 0.581 | 0.649 |
Specificity | 0.982 | 0.982 | 0.982 | 0.767 | 0.976 | 0.754 | 0.973 | 0.972 |
PPV | 0.623 | 0.656 | 0.685 | 0.32 | 0.839 | 0.27 | 0.846 | 0.868 |
NPV | 0.944 | 0.951 | 0.956 | 0.968 | 0.995 | 0.952 | 0.86 | 0.882 |
Accuracy | 0.93 | 0.937 | 0.941 | 0.767 | 0.974 | 0.744 | 0.856 | 0.875 |
ASD (2,2) Sensitivity | 0.331 | 0.408 | 0.453 | 0.64 | 0.926 | 0.445 | 0.424 | 0.511 |
Specificity | 1 | 1 | 1 | 0.95 | 0.999 | 0.951 | 0.999 | 0.999 |
PPV | 0.673 | 0.719 | 0.761 | 0.635 | 0.987 | 0.509 | 0.864 | 0.904 |
NPV | 0.932 | 0.939 | 0.945 | 0.96 | 0.993 | 0.941 | 0.816 | 0.843 |
Accuracy | 0.933 | 0.941 | 0.945 | 0.919 | 0.992 | 0.901 | 0.827 | 0.853 |