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Fig. 1 | BMC Medical Research Methodology

Fig. 1

From: Inverse probability weighting to estimate causal effect of a singular phase in a multiphase randomized clinical trial for multiple myeloma

Fig. 1

a Study design of a phase III open-label RCT carried out in 73 Italian hospitals. Eligible untreated symptomatic multiple myeloma patients aged 18–65 years were randomized (1:1 ratio) to receive experimental (Arm A) versus standard (Arm B) treatment as induction therapy before a maximum of two planned autologous stem cell transplantations (ASCT) followed by a consolidation phase consisting on the same arm of therapy as induction phase. b Miming an Ad hoc RCT to evaluate the role of consolidation therapy. Eligible untreated symptomatic multiple myeloma patients aged 18–65 years who had received at least 1 ASCT after having been prepared with induction therapy (Experimental or Standard) were randomized to receive the same arm of therapy (Experimental or Standard) as a consolidation phase or to not receive any therapy

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