Evaluation of surrogate measures of insulin sensitivity - correlation with gold standard is not enough

Table 1 Common surrogate measures with formulas

	Surrogate measure	Formula
OGTT-based indices	Stumwoll	18.3−0.271·BMI−0.0052·
		I₁₂₀−0.27·G₉₀
	Matsuda	\(10,000\left (\sqrt {G_{0}\!\cdot \! I_{0}\!\cdot \! G_{mean}\cdot I_{mean}}\right)\)
Fasting indices	HOMA-IR	(G₀·I₀)/22.5
	QUICKI	1/(logG₀+logI₀)
	FIRI	(G₀·I₀)/25
	Revised QUICKI	1/(logG₀+logI₀+logNEFA)
	Ratio of fasting insulin to glucose	I₀/G₀
	Ratio of fasting glucose to insulin	G₀/I₀

BMI, body mass index; G₀, fasting gluc, glucose 90 min after administration of glucose; G_mean, mean glucose during OGTT; I₀, fasting insulin; I₁₂₀, insulin 120 min after administration of insulin; I_mean, mean insulin during OGTT; NEFA, non-esterified fatty acids

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