Multivariate meta-analysis of critical care meta-analyses: a meta-epidemiological study

Moran, John L.

doi:10.1186/s12874-021-01336-4

BMC Medical Research Methodology

Table 3 Details of third outcomes for meta-analyses

From: Multivariate meta-analysis of critical care meta-analyses: a meta-epidemiological study

Meta_analysis	Reference	Study	Second_outcome	Third_outcome	Year	Third outcome RCT no.	Third outcome total patients	Third outcome total events	I^2	Third outcome sse graphics	Third outcome sse test
Griesdale	[34]	Bivariate	Hypoglcaemia		2009
Annane	[35]	Bivariate	Shock reversal		2009
Bangalore	[36]	Trivariate	Non-fatal MI	Non-fatal stroke	2008	13	11,233	55	0.00	ok	0.260
Marik	[37]	Trivariate	Infection	Hospital LOS	2008	4	835	N/A	76.21	query	0.002
Marik	[37]	Trivariate	Hospital LOS	Infection	2008	4	144	74	0.00	ok	0.596
Marik	[37]	Trivariate	Hospital LOS	Infection	2008	7	300	120	60.37	ok	0.710
Chan	[38]	Trivariate	VAP	MV length	2007	5	1597	N/A	23.90	ok	0.400
Gonzalez	[39]	Bivariate	Rebleeding		2008
Ho	[40]	Trivariate	Pneumonia	ICULOS	2006	5	336		0.00	ok	0.410
Ho	[41]	Bivariate	ICU LOS		2008
Siempos	[42]	Bivariate	VAP		2010
Singh	[43]	Bivariate	Pneumonia		2009
Peterson	[44]	Bivariate	Neurological outcome		2008
Silvestri	[45]	Bivariate	infection		2007
Whitlock	[46]	Trivariate	New Atrial fibrillation	Bleed post-operative	2008	4	513	N/A	7.89	ok	0.120
Piccini	[47]	Trivariate	CVS death	Cardiomyopathy	2009	15	8522	1607	3.39	ok	0.228
Landoni	[48]	Bivariate	MI		2010
Brar	[49]	Trivariate	MI	TVR	2009	13	7352	561	35.99	query	0.001
Landoni	[50]	Trivariate	Acute kidney injury	Hospital LOS	2007	8	695	N/A	0.00	ok	0.693
Mazaki	[51]	Bivariate	Infection		2008
Masip	[52]	Bivariate	Intubation		2005
Oldani	[53]	Trivariate	Infection	Hospital LOS	2015	15	2297	N/A	59.35	query	0.710
Szakmany	[54]	Trivariate	VAP	MV length	2015	9	1623	N/A	76.73	query	0.532
Alkhawaja	[55]	Trivariate	Pneumonia	ICU LOS	2015	6	484	N/A	17.63	ok	0.208
Van Zanten	[56]	Trivariate	Infection	Hospital LOS	2015	6	535	N/A	61.28	query	0.540
Wan	[57]	Bivariate	Hospital LOS	MV length	2015	7	617	N/A	88.84	query	0.562
Teo	[58]	Bivariate	Clinical response		2014
Manzanares	[59]	Trivariate	Infection	MV length	2012	5	368	N/A	65.48	query	0.510
Tian	[60]	Trivariate	Pneumonia	Hospital LOS	2018	8	517	N/A	12.46	ok	0.624
Rhodes	[61]	Bivariate	Cinical cure		2018
Nunez-Patino	[62]	Trivariate	Neurological outcome	ICU LOS	2018	5	763		0.00	ok	0.194
Kawano-Dourado	[63]	Bivariate	RRT		2018
Dallimore	[64]	Bivariate	ICU LOS		2018
Chong	[65]	Bivariate	Myocardial infarction		2018
Yang	[66]	Trivariate	Renal function recovery	RRT time	2017	3	576		97.92	query	0.003
Osadnik	[67]	Trivariate	Hospital LOS	MV	2017	12	846	196	84.57	query	0.043
Lu	[68]	Trivariate	ICU LOS	MV length	2017	7	495	N/A	67.15	ok	0.680
Chen	[69]	Trivariate	ICU LOS	RRT	2017	8	1908	129	0.00	ok	0.413
Qureshi	[70]	Bivariate	Acute kidney injury		2016
Elke	[71]	Trivariate	Infection	Hospital LOS	2016	6	2684	N/A	0.00	ok	0.686
Parikh	[72]	Trivariate	Hospital LOS	ICU LOS	2016	10	2782	421	50.85	ok	0.396
Davies	[73]	Trivariate	VAP	Hospital LOS	2017	10	2747	N/A	72.54	ok	0.340
Abroug	[74]	Bivariate	Clinical response		2014
Manzanares	[75]	Bivariate	infection		2016
Peter	[76]	Trivariate	Mechanical ventilation	Hospital LOS	2002	10	398	N/A	88.06	query	0.246
Wang	[77]	Trivariate	Rebleeding	Surgery	2010	5	949	22	0.00	ok	0.570
Tao	[78]	Trivariate	Infection	MV length	2016	4	288	N/A	52.89	query	0.036
Tang	[79]	Trivariate	Antibiotic exposure	ICU LOS	2009	6	1386	N/A	99.01	query	0.674
Muscedere	[80]	Trivariate	VAP	MV length	2011	4	458	N/A	6.27	ok	0.412

LOS Length of stay (days), ICU Intensive care unit, VAP Ventilator associated pneumonia, CVS Cardiovascular, MV Mechanical ventilation, TVR Target vessel revascularization, RRT Renal replacement therapy, MI Myocardial infarction, Ok Visual assessment of contour-enhanced revealed no problematic asymmetry, query Visual assessment of contour-enhanced revealed problematic asymmetry

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