An improved method for the effect estimation of the intermediate event on the outcome based on the susceptible pre-identification

Table 3 The effect of the disease progression on the survival of MF patients

Variables	Real effect β_z	exCox1 (Existing)		exCox2-LRM (Existing)		exCox3-RITI (Proposed)
Variables	Real effect β_z	\( {\hat{\beta}}_z \)	P value	\( {\hat{\beta}}_z \)	P value	\( {\hat{\beta}}_z \)	P value
TCF	1.6	1.006	< 0.001	1.335	< 0.001	2.286	< 0.001
Stage	0.9	0.431	< 0.001	0.841	< 0.001	1.258	< 0.001
Age	0.7	1.356	< 0.001	1.115	< 0.001	1.067	< 0.001
Progress	2.0	3.139	< 0.001	3.575	< 0.001	2.724	< 0.001

ISSN: 1471-2288