| OPUS | OrPHeUS | EXPOSURE |
---|---|---|---|
Study identifier | NCT02126943 | NCT03197688 | EUPAS19085 |
Study type | Multi-centre, prospective drug registry of PH patients newly treated with macitentan | Multi-centre, retrospective medical chart review of PH patients newly treated with macitentan | Multi-centre, prospective cohort study of patients with PAH newly treated with either selexipag or any other PAH-specific therapy |
Region | USA | USA | Europe and Canada |
Date ranges | Apr 2014 – Apr 2020 | Oct 2013 to Mar 2017 | Sept 2017 – ongoinga |
Patients in database, N | 2722 | 3142 | 758 |
Age at enrolment in database, mean (SD), years [N] | 60.93 (14.15) [N = 2682] | 60.21 (15.06) [N = 3060] | 59.96 (15.07) [N = 752] |
Gender, % | |||
 Female | 71.6 | 72.2 | 68.6 |
 Male | 26.9 | 25.2 | 31.3 |
 Missing | 1.4 | 2.5 | 0.1 |
Source data format | |||
 Conditions | MedDRA and free text | MedDRA and free text | MedDRA and free text |
 Drugs | WHODrug and free text | WHODrug and free text | WHODrug and free text |