Table 1 Utility and cost values, base case analysis
Utilities | ||
State | Mean (SD) | Source |
Pettersson score 0–4 | 0.82 (± 0.13) | Fischer, K. et al.[6] |
Pettersson score 5–12 | 0.81 (± 0.12) | |
Pettersson score 13–21 | 0.77 (± 0.13) | |
Pettersson score 22–39 | 0.74 (± 0.12) | |
Pettersson score 40–78 | 0.72 (± 0.11) | |
Orthopaedic surgery | -0.39 (± 0.04) | Ballal, R. D. et al.[19] Utility decrement is assumed to last for 30.4 days. Standard deviation not reported, 10% assumed |
Hospitalisation due to major bleed | -0.39 (± 0.04) | Assumption. Utility decrement is assumed to be the same as for orthopaedic surgery but for a shorter time period (3.6 days) |
Costs | ||
Input | Mean (CNY) | Source |
BAY 81–8973 per IU | 4.488 | Huo et al.[20] |
rAHF-PFMper IU | 4.488 | Huo et al.[20] |
Hospitalization for major bleed | 74,122 | Expert opinion, based on survey |
Physician visit | 500 | Expert opinion, based on survey |
Cost of orthopaedic surgery | 300,465 | Expert opinion, based on survey |
Rehabilitation costs | 937.50 | Expert opinion, based on survey |
Total compensation per hour | 25.40 | National Bureau of Statistics of China[21] |
Resource Use | ||
Input | Unit/Frequency | Source |
Extra dose for treatment of bleed – BAY 81–8973 | 24.11 IU/kg | Calculated |
Extra dose for treatment of bleed – rAHF-PFM | 24.55 IU/kg | Calculated |
Doctor visits (with or without joint bleeds) | 12 / year | Expert opinion |
Retirement age | 60 | China labour statistics[22] |
Full time employment | 45.6% | Sun et al.[23] |
Missing days of work, annual | 3.40 | Chen et al. 2017[24] |