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Table 5 The clinical performance of the WHO non-laboratory-based model among 6796 adults in Fasa cohort study

From: Laboratory-based versus non-laboratory-based World Health Organization risk equations for assessment of cardiovascular disease risk

 

Sensitivity

Specificity

PPV

NPV

MCC

% (95%CI)

% (95%CI)

% (95%CI)

% (95%CI)

WHO non-laboratory model

 Cut-off point of 20% for laboratory-based and non-laboratory-based models

  Male

   All males

59.0 (50.6–67.3)

98.8 (98.4–99.2)

68.7 (60.2–77.2)

98.2 (97.7–98.7)

0.61

    < 60 years old

25.7 (11.2–40.2)

99.8 (99.6–100)

64.3 (39.2–89.4)

99.0 (98.6–99.4)

0.40

   ≥ 60 years old

70.7 (61.7–79.7)

93.3 (91.1–95.6)

69.3 (60.3–78.3)

93.7 (91.5–95.9)

0.64

  Female

   All females

35.5 (25.8–45.2)

99.6 (99.3–99.8)

70.2 (57.1–83.3)

98.3 (97.9–98.7)

0.49

    < 60 years old

35.7 (10.6–60.8)

100 (99.9–100)

83.3 (53.5–100)

99.8 (99.5–99.9)

0.54

   ≥ 60 years old

35.4 (24.9 -45.9)

97.5 (96.2–98.9)

68.3 (54.1–82.5)

91.0 (88.6–93.4)

0.44

 Cut-off point of 20% for laboratory-based and 10% for non-laboratory-based model

  Male

   All males

99.8 (95.2–1.00)

76.6 (75.1–78.1)

15.6 (13.2–18.1)

99.9 (99.7–100)

0.34

    < 60 years old

91.4 (82.2–100)

87.4 (86.1–88.7)

9.0 (6.1–12.0)

99.9 (99.7–100)

0.27

   ≥ 60 years old

100 (100–100)

17.0 (13.6–20.4)

20.4 (16.9–24.1)

100 (100–100)

0.19

  Female

   All females

100 (100–100)

83.2 (82.0–84.4)

13.5 (11.0–16.1)

100 (100–100)

0.33

    < 60 years old

100 (100–100)

94.3 (93.5–95.1)

7.5 (3.7–11.0)

100 (100–100)

0.27

   ≥ 60 years old

100 (100–100)

19.9 (16.5–23.3)

15.7 (12.5–18.9)

100 (100–100)

0.18

  1. PPV Positive predictive value, NPV Negative predictive value, MCC Matthews correlation coefficient