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Table 1 Clinical characteristics and the use of OA-related medications and procedures by patient type using claims data

From: Use of electronic health data to identify patients with moderate-to-severe osteoarthritis of the hip and/or knee and inadequate response to pain medications

Characteristics, N (%)

Patients without OA a (N = 47)

Case Patientsa (N = 360)

Comparator Patientsa (N = 83)

Obesityb

4 (8.5)

101 (28.1)

16 (19.3)

Pain-related conditions

 Joint pain of hip

2 (4.3)

46 (12.8)

5 (6.0)

 Joint pain of knee

0 (0.0)

83 (23.1)

13 (15.7)

 Joint pain in other site(s)

15 (31.9)

148 (41.1)

29 (34.9)

 Back pain

0 (0.0)

10 (2.8)

2 (2.4)

 Unspecified pain

12 (25.5)

168 (46.7)

19 (22.9)

Other comorbidities

 Hypertension

11 (23.4)

153 (42.5)

27 (32.5)

 Diabetes

12 (25.5)

47 (13.1)

12 (14.5)

 Gastroesophageal reflux

4 (8.5)

90 (25.0)

9 (10.8)

 Depression

3 (6.4)

56 (15.6)

8 (9.6)

 Anxiety

4 (8.5)

47 (13.1)

8 (9.6)

 Drug or alcohol abuse

0 (0.0)

16 (4.4)

3 (3.6)

 Insomnia

0 (0.0)

14 (3.9)

4 (4.8)

Charlson Comorbidity Index category

 0

32 (68.1)

230 (63.9)

58 (69.9)

 1

9 (19.1)

64 (17.8)

14 (16.9)

 2

1 (2.1)

26 (7.2)

4 (4.8)

 ≥ 3

5 (10.6)

40 (11.1)

7 (8.4)

Medication use

 Any NSAIDs

7 (14.9)

148 (41.1)

22 (26.5)

  Topical NSAIDs

0 (0.0)

37 (10.3)

7 (8.4)

  COX-2

0 (0.0)

37 (10.3)

7 (8.4)

  Non-selective NSAIDs

7 (14.9)

117 (32.5)

17 (20.5)

 Any opioids

13 (27.7)

178 (49.4)

20 (24.1)

  Short-acting opioids

7 (14.9)

145 (40.3)

15 (18.1)

  Long-acting opioids

0 (0.0)

4 (1.1)

1 (1.2)

  Opioid mixed mechanismb

7 (14.9)

66 (18.3)

7 (8.4)

 Oral corticosteroids

0 (0.0)

1 (0.3)

(0.0)

 H2 blockers

3 (6.4)

33 (9.2)

9 (10.8)

IA steroids injections

10 (21.3)

288 (80.0)

21 (25.3)

HA injections

1 (2.1)

89 (24.7)

3 (3.6)

OA related Surgeries

 Hip replacement

0 (0.0)

80 (22.2)

2 (2.4)

 Knee replacement

1 (2.1)

134 (37.2)

4 (4.8)

Nerve Block Ablation

7 (14.9)

208 (57.8)

14 (16.9)

  1. aBased on a total of 490 patients who had available claims data. Non-OA group refers to patients without evidence of OA of hip or knee; OA case group refers to patients with all three OA features – OA of hip/knee, moderate-to-severe disease and inadequate response to two or more pain-related medications; comparator patients are all other patients with OA of hip/knee
  2. bDefined using relevant diagnosis and procedure codes, and body mass index
  3. Including tapentadol and tramadol
  4. Abbreviations: COX-2  Cyclooxygenase-2, OA Osteoarthritis, HA  Hyaluronic acid, IA  Intraarticular, NSAIDs Nonsteroidal anti-inflammatory drugs