Table 2 DISCOVER trial: primary outcome analysis

Original analysis on rate ratio scale

Group

No. subjects

PYFU

Incident HIV infections

Incidence rate (per 100 PYFU)

Rate ratio (95% CI)

TDF/FTC

2693

4386

11

0.251

REF

TAF/FTC

2694

4370

6

0.137

0.55 (0.20, 1.48)

Re-analysis using an averted infections framework

Group

PYFU

Observed infections

Predicted infections^a

Averted infections

Averted infections ratio (95% CI)

TDF/FTC

4386

11

90.4

79.4

REF

TAF/FTC

4370

6

90.0

84.0

1.06 (0.96–1.17)