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Fig. 4 | BMC Medical Research Methodology

Fig. 4

From: Increase in power by obtaining 10 or more controls per case when type-1 error is small in large-scale association studies

Fig. 4

Expected p-value vs number of controls per cases, by the number of cases in a GWAS (α = 5 × 10–8) for OR = 1.1 and control minor allele frequency varying across plots from 0.5, 0.1, 0.05, 0.01. Dotted lines are expected p = α = 5 × 10–8 and “stringent” expected p = 3 × 10–12. P-values below 10–50 are not plotted. Both axes are on a log scale

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BMC Medical Research Methodology

ISSN: 1471-2288

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