Search strategy | |
---|---|
Group | keywords |
Clinical trials - phase II-III | Phase IIb-IIIb, 2b-3b, 2b/3b, IIb/IIIb, 2b-3, 2b/3, IIb/III, 2–3, II-III. |
Randomised controlled trials | randomiz* or randomis* or trial* |
Adaptive designs/traditional group sequential design | adapt*, design* or rule |
seamless | |
group sequential | |
sample size re-estimation, re-estimations, sample size adjustment or sample size modification | |
MAMS or multi-arm multi-stage or multi* arm or multi* stage or drop the loser or pick the winner or play the winner or two-stage adaptive | |
treatment switching or treatment adaptive | |
adaptive dose*. | |
treatment switching or treatment adaptive | |
adaptive hypothesis | |
biomarker adaptive or biomarker adaptive design or biomarker or enrichment | |
multiple adaptive | |
interim monitoring or interim monitor or Bayesian adaptive or stopping rule* or stopping boundar*, interim | |
adaptive clinical trial* or adaptive design or flexible design or adaptive method | |
Cardiovascular Diseases | Cardiovascular Diseases, Cardiovascular disease |