From: Prescription Sequence Symmetry Analysis (PSSA) to assess prescribing cascades: a step-by-step guide
Study population | Patients using index before marker | Patients using marker before index | cSR | SRnull | aSR (95% CI) | |
---|---|---|---|---|---|---|
Any ACEi usersa | 3,188 | 2,152 | 1,036 | 2.08 | 1.09 | 1.91 (1.84-1.99) |
Sole ACEi usersb | 1,170 | 767 | 403 | 1.90 | 1.09 | 1.74 (1.62-1.86) |
Any beta blocker users | 3,035 | 1,937 | 1,098 | 1.76 | 1.06 | 1.66 (1.58-1.73) |
Sole beta blocker users | 1,228 | 739 | 489 | 1.51 | 1.05 | 1.44 (1.33-1.56) |
Any high ceiling diuretic users | 688 | 405 | 283 | 1.43 | 1.04 | 1.38 (1.23-1.53) |
Sole high ceiling diuretic users | 342 | 200 | 142 | 1.41 | 1.04 | 1.36 (1.14-1.57) |
Combination: use of two subgroupsc | 2,419 | 1,695 | 724 | 2.34 | 1.07 | 2.18 (2.10-2.27) |
Combination: use of three or more subgroups | 1,544 | 1,167 | 377 | 3.10 | 1.10 | 2.81 (2.69-2.93) |