From: A Bayesian approach to pilot-pivotal trials for bioequivalence assessment
Comparator | \(\eta\) | (w, 1 - w) | Sc. 1 | Sc.Ā 2 | Sc.Ā 3 | Sc.Ā 4 | Sc.Ā 5 | Sc.Ā 6 | Sc.Ā 7 | Sc.Ā 8 | Sc.Ā 9 |
---|---|---|---|---|---|---|---|---|---|---|---|
GMR = 0.5 | GMRĀ = 0.7 | GMRĀ = 0.8 | GMRĀ = 0.9 | GMRĀ = 1.0 | GMRĀ = 1.1 | GMRĀ = 1.25 | GMRĀ = 1.43 | GMRĀ = 2.0 | |||
CI methodĀ (\(\alpha\) = 5%) | |||||||||||
Ā Ā Ā Ā Ā C\(_\text {max}\) | Ā | Ā | 0 | 0.24 | 4.23 | 20.35 | 31.19 | 21.74 | 4.31 | 0.19 | 0 |
Ā Ā Ā Ā Ā AUC | Ā | Ā | 0 | 0.01 | 4.45 | 51.68 | 88.20 | 56.90 | 5.20 | 0 | 0 |
CI methodĀ (\(\alpha\) = 10%) | |||||||||||
Ā Ā Ā Ā Ā C\(_\text {max}\) | Ā | Ā | 0 | 0.58 | 9.11 | 38.61 | 56.28 | 41.00 | 9.81 | 0.55 | 0 |
Ā Ā Ā Ā Ā AUC | Ā | Ā | 0 | 0.03 | 9.33 | 67.84 | 95.52 | 72.91 | 9.94 | 0.05 | 0 |
CI methodĀ (\(\alpha\) = 20%) | |||||||||||
Ā Ā Ā Ā Ā C\(_\text {max}\) | Ā | Ā | 0 | 1.71 | 19.56 | 59.70 | 79.67 | 62.38 | 20.35 | 1.67 | 0 |
Ā Ā Ā Ā Ā AUC | Ā | Ā | 0 | 0.14 | 19.37 | 82.84 | 98.87 | 86.42 | 20.03 | 0.15 | 0 |
PAR method | |||||||||||
Ā Ā Ā Ā Ā C\(_\text {max}\) | Ā | Ā | 0 | 1.22 | 16.69 | 55.44 | 76.41 | 58.89 | 17.90 | 1.29 | 0 |
Ā Ā Ā Ā Ā AUC | Ā | Ā | 0 | 0.10 | 16.53 | 80.18 | 98.56 | 84.10 | 17.28 | 0.11 | 0 |
Proposed method | |||||||||||
Ā Ā Ā Ā Ā C\(_\text {max}\) | 0.85 | (0.9, 0.1) | 0 | 1.99 | 21.60 | 62.75 | 81.90 | 64.61 | 21.22 | 1.84 | 0 |
Ā Ā Ā Ā Ā AUC | 0.85 | (0.9,Ā 0.1) | 0 | 0.15 | 20.32 | 83.99 | 99.02 | 86.95 | 20.72 | 0.19 | 0 |
Ā Ā Ā Ā Ā C\(_\text {max}\) | 0.85 | (1.0, 0) | 0 | 5.33 | 37.07 | 78.48 | 92.88 | 80.91 | 36.83 | 4.83 | 0 |
Ā Ā Ā Ā Ā AUC | 0.85 | (1.0, 0) | 0 | 0.75 | 36.33 | 92.73 | 99.85 | 94.36 | 36.14 | 0.70 | 0 |
Ā Ā Ā Ā Ā C\(_\text {max}\) | 0.95 | (1.0, 0) | 0 | 1.53 | 18.52 | 58.14 | 78.13 | 59.66 | 18.41 | 1.32 | 0 |
Ā Ā Ā Ā Ā AUC | 0.95 | (1.0, 0) | 0 | 0.13 | 17.89 | 81.36 | 98.67 | 84.64 | 17.89 | 0.13 | 0 |