Characteristics | PreprintāArticle RCTs nā=ā109 (%) | RCTs with consistent data nā=ā81 (%) | RCTs with added/ deleted outcomes nā=ā20* (%) | RCTs with change in effect estimate nā=ā9* (%) | |
---|---|---|---|---|---|
Sample size, median (IQR) | 150 (71ā464) | 149 (66ā420) | 129 (85ā663) | 606 (240ā1225) | |
Delayā , median (IQR) | 121 (73ā187) | 128 (79ā187) | 91 (27ā153) | 127 (99ā210) | |
Registration timing, n (%) | Prospective | 83 (76) | 62 (77) | 14 (70) | 8 (89) |
Retrospective | 25 (23) | 18 (22) | 6 (30) | 1 (11) | |
Not reported/unclear | 1 (1) | 1 (1) | 0 | 0 | |
Funding type, n (%) | Industry/mixed | 65 (60) | 45 (56) | 16 (80) | 5 (56) |
Public | 34 (31) | 28 (35) | 1 (5) | 4 (44) | |
Others | 10 (9) | 8 (10) | 3 (15) | 0 | |
Study centers, n (%) | Single | 30 (28) | 28 (35) | 2 (10) | 0 |
Multicenter | 79 (72) | 53 (65) | 18 (90) | 9 (100) | |
Overall risk of biasā, n (%) | Low | 13 (12) | 7 (9) | 6 (30) | 1 (11) |
Some concerns | 87 (80) | 66 (81) | 13 (65) | 8 (89) | |
High | 9 (8) | 8 (10) | 1 (5) | 0 | |
Setting, n (%) | Hospital | 93 (85) | 67 (83) | 18 (90) | 8 (89) |
Outpatient clinic | 16 (15) | 14 (17) | 2 (10) | 1 (11) | |
Geographical locationā”, n (%) | High-income countries | 42 (39) | 30 (37) | 8 (40) | 5 (56) |
Low-/middle-income countries | 49 (45) | 39 (48) | 7 (35) | 3 (33) | |
Countries of different income levels | 18 (17) | 12 (15) | 5 (25) | 1 (11) | |
Preprint postĀ§, n (%) | <ā6 months | 21 (19) | 14 (17) | 6 (30) | 1 (11) |
6ā12 months | 45 (41) | 32 (40) | 10 (50) | 3 (33) | |
>ā12 months | 43 (39) | 35 (43) | 4 (20) | 5 (56) |