Analysis* | Estimand 1 (all KRAS assessable patients) hazard ratio (95% CI) | Estimand 2 (KRAS WT) hazard ratio (95% CI) |
---|---|---|
Expected ‘truth’§ | 0.76–0.77 (0.60–0.98) | 0.55–0.73 (0.41–0.93) |
ITT | 0.97 (0.79–1.18) | 0.99 (0.75–1.29) |
IPCW 1 (primary analysis, inclusive model, stabilised weights) | 0.75 (0.59–0.95) | 0.55 (0.28–1.09) |
IPCW 5 (secondary analysis, inclusive model, stabilised weights) | 0.75 (0.59–0.96) | 0.65 (0.50–0.85) |
TSEsimp 1 (primary analysis, inclusive model, with re-censoring) | 0.64 (0.46–0.98) | 0.44 (0.24–0.95) |
TSEsimp 9 (secondary analyses, inclusive model, with re-censoring) | 0.70 (0.54–0.90) | 0.59 (0.43–0.78) |
TSEgest 1 (primary analysis, inclusive model, with re-censoring) | 0.54 (0.30–1.51) | 0.31 (0.13–2.12) |
TSEgest 9 (secondary analyses, inclusive model, with re-censoring) | 0.79 (0.57–0.99) | 0.67 (0.46–0.86) |
RPSFTM 1 (with re-censoring, ever treated, interval bisection) | 0.91 (0.49–1.68) | 0.87 (0.02–35.88) |