Dose Levels | ||||||||
---|---|---|---|---|---|---|---|---|
-1 | 0 | 1 | 2a | 2b | 3 | Stop | ||
Scenario | Prior DLT | 0.01 | 0.04 | 0.08 | 0.16 | 0.25 | 0.35 | |
1: TD25 @-1 | True DLT rate | 0.25 | 0.4 | 0.45 | 0.5 | 0.55 | 0.6 | |
P(select) | 0.68 | 0.18 | 0.05 | 0.01 | 0 | 0 | 0.08 | |
% of patients | 39 | 32 | 20 | 6 | 3 | 0 | ||
Mean number of patients | 10.17 | 8.46 | 5.33 | 1.67 | 0.69 | 0.07 | ||
2: TD25 @0 | True DLT rate | 0.12 | 0.25 | 0.4 | 0.45 | 0.5 | 0.55 | |
P(select) | 0.23 | 0.51 | 0.2 | 0.03 | 0.02 | 0 | 0.01 | |
% of patients | 17 | 35 | 29 | 11 | 6 | 1 | ||
Mean number of patients | 5.24 | 10.48 | 8.75 | 3.4 | 1.83 | 0.26 | ||
3: TD25 @1 | True DLT rate | 0.09 | 0.12 | 0.25 | 0.4 | 0.45 | 0.5 | |
P(select) | 0.02 | 0.2 | 0.55 | 0.14 | 0.09 | 0.01 | <0.01 | |
% of patients | 4 | 20 | 34 | 23 | 16 | 3 | ||
Mean number of patients | 1.22 | 6.41 | 10.97 | 7.23 | 5.14 | 1.02 | ||
4: TD25 @2a | True DLT rate | 0.06 | 0.09 | 0.12 | 0.25 | 0.4 | 0.45 | |
P(select) | 0 | 0.02 | 0.22 | 0.48 | 0.23 | 0.05 | <0.01 | |
% of patients | 1 | 12 | 20 | 31 | 25 | 11 | ||
Mean number of patients | 0.47 | 3.88 | 6.74 | 10.43 | 8.2 | 3.5 | ||
5: TD25 @2b | True DLT rate | 0.03 | 0.06 | 0.09 | 0.12 | 0.25 | 0.4 | |
P(select) | 0 | 0 | 0.02 | 0.3 | 0.43 | 0.25 | 0 | |
% of patients | 1 | 10 | 12 | 24 | 28 | 25 | ||
Mean number of patients | 0.25 | 3.36 | 4.15 | 8.17 | 9.33 | 8.33 | ||
6: TD25 @3 | True DLT rate | 0.01 | 0.03 | 0.06 | 0.09 | 0.12 | 0.25 | |
P(select) | 0 | 0 | 0 | 0.09 | 0.13 | 0.78 | 0 | |
% of patients | 0 | 10 | 11 | 18 | 18 | 42 | ||
Mean number of patients | 0.1 | 3.13 | 3.49 | 5.46 | 5.6 | 13.14 | ||
7: Equal steps in DLT rate | True DLT rate | 0.05 | 0.1 | 0.15 | 0.2 | 0.25 | 0.3 | |
P(select) | 0 | 0.03 | 0.12 | 0.31 | 0.28 | 0.26 | <0.01 | |
% of patients | 2 | 13 | 18 | 26 | 23 | 19 | ||
Mean number of patients | 0.55 | 4.03 | 5.72 | 8.32 | 7.15 | 5.96 | ||
8: All toxic | True DLT rate | 0.5 | 0.6 | 0.65 | 0.7 | 0.75 | 0.8 | |
P(select) | 0.26 | 0 | 0 | 0 | 0 | 0 | 0.74 | |
% of patients | 56 | 26 | 15 | 2 | 0 | 0 | ||
Mean number of patients | 9.05 | 4.27 | 2.4 | 0.37 | 0.04 | 0 |