Dose Levels | ||||||||
---|---|---|---|---|---|---|---|---|
-1 | 0 | 1 | 2a | 2b | 3 | Stop | ||
Scenario | Prior DLT | 0.01 | 0.04 | 0.08 | 0.16 | 0.25 | 0.35 | |
9: TD25 @-1 | True DLT rate | 0.25 | 0.4 | 0.45 | 0.55 | 0.5 | 0.6 | |
P(select) | 0.67 | 0.19 | 0.05 | 0 | 0.01 | 0 | 0.08 | |
% of patients | 39 | 32 | 20 | 6 | 3 | 0 | ||
Mean number of patients | 10.19 | 8.43 | 5.27 | 1.6 | 0.68 | 0.07 | ||
10: TD25 @0 | True DLT rate | 0.12 | 0.25 | 0.4 | 0.5 | 0.45 | 0.55 | |
P(select) | 0.23 | 0.52 | 0.2 | 0.02 | 0.02 | 0 | 0.01 | |
% of patients | 18 | 36 | 29 | 11 | 6 | 1 | ||
Mean number of patients | 5.24 | 10.64 | 8.82 | 3.16 | 1.85 | 0.24 | ||
11: TD25 @1 | True DLT rate | 0.09 | 0.12 | 0.25 | 0.45 | 0.4 | 0.5 | |
P(select) | 0.02 | 0.2 | 0.55 | 0.09 | 0.14 | 0.01 | <0.01 | |
% of patients | 4 | 20 | 34 | 21 | 17 | 3 | ||
Mean number of patients | 1.16 | 6.43 | 11.07 | 6.83 | 5.6 | 1.07 | ||
12: TD25 @2a | True DLT rate | 0.06 | 0.09 | 0.12 | 0.25 | 0.15 | 0.45 | |
P(select) | 0 | 0.01 | 0.08 | 0.44 | 0.33 | 0.14 | <0.01 | |
% of patients | 1 | 11 | 16 | 30 | 24 | 18 | ||
Mean number of patients | 0.48 | 3.78 | 5.24 | 10.1 | 7.9 | 6.07 | ||
13: TD25 @2b | True DLT rate | 0.03 | 0.06 | 0.09 | 0.35 | 0.25 | 0.4 | |
P(select) | 0 | 0 | 0.15 | 0.31 | 0.43 | 0.11 | 0 | |
% of patients | 1 | 11 | 18 | 30 | 28 | 14 | ||
Mean number of patients | 0.25 | 3.5 | 5.9 | 9.82 | 9.14 | 4.54 | ||
14: TD25 @3 | True DLT rate | 0.01 | 0.03 | 0.06 | 0.12 | 0.09 | 0.25 | |
P(select) | 0 | 0 | 0 | 0.13 | 0.09 | 0.78 | 0 | |
% of patients | 0 | 10 | 11 | 19 | 16 | 43 | ||
Mean number of patients | 0.1 | 3.13 | 3.51 | 5.88 | 5.06 | 13.13 | ||
15: Equal steps in DLT rate | True DLT rate | 0.05 | 0.1 | 0.15 | 0.25 | 0.2 | 0.3 | |
P(select) | 0 | 0.02 | 0.12 | 0.32 | 0.27 | 0.26 | <0.01 | |
% of patients | 2 | 13 | 19 | 27 | 22 | 18 | ||
Mean number of patients | 0.54 | 4.02 | 5.93 | 8.56 | 6.89 | 5.75 | ||
16: All toxic | True DLT rate | 0.5 | 0.6 | 0.65 | 0.75 | 0.7 | 0.8 | |
P(select) | 0.27 | 0 | 0 | 0 | 0 | 0 | 0.73 | |
% of patients | 56 | 27 | 15 | 2 | 0 | 0 | ||
Mean number of patients | 9.01 | 4.28 | 2.39 | 0.38 | 0.05 | 0 |