| Clinical healthcare example | GPG maintenance scenario |
---|---|---|
Objective | To detect whether there is arterial hypertension | To detect whether a recommendation is outdated |
Target condition definition | We consider high blood pressure to be prevalent when there is at least 140Â mmHg systolic arterial pressure over 90Â mmHg diastolic arterial pressure | We consider the recommendation to be outdated when at least one new relevant peer-reviewed article is published after the previous search date |
Detection variable | Pressure on artery walls | New available evidence |
Detection test | Auscultatory sphygmomanometer | Literature search in MEDLINE |
Detection test protocol | Three blood pressure measurements are taken one to two minutes apart after the patient is seated in a quiet environment for five minutes. The last two blood pressure measurements are averaged | A sensitive search string for MEDLINE is constructed. Search results are screened on title and abstracts by two independent assessors. Conflicts are resolved by a third independent assessor. The resulting potentially relevant articles are read and selected by two assessors independently based on the full text. A third assessor resolves any conflict in the full text selection |
Detection test threshold | 140Â mmHg systolic arterial pressure over 90Â mmHg diastolic arterial pressure | Any new peer-reviewed scientific article published after the previous search date |